Research Article | Volume: 4, Issue: 4, April, 2014

Anticoagulant and antibacterial activities of polysaccharides of red algae Corallina collected from Lebanese coast

Carine Sebaaly,  Sahar Kassem,  Elena Grishina,  Hussein Kanaan,  Alaa Sweidan,  M. Said Chmit,  Hussein M. Kanaan   
Carine Sebaaly1, Sahar Kassem2, Elena Grishina3, Hussein Kanaan4, Alaa Sweidan4, M. Said Chmit1, Hussein M. Kanaan1

1Laboratory of Biotechnology of Natural Substances and Health Products, Faculty of Pharmacy, Lebanese University, Beirut, Lebanon,

2Laboratory of the Medical Analyses Center, Faculty of Public Health, Lebanese University, Hadath, Lebanon,

3National Academy of Sciences of Ukraine STATE SCIENTIFIC INSTITUTION, INSTITUTE FOR SINGLE CRYSTALS,

4Laboratory of Microbiology, Department of Biology, Faculty of Sciences I, Lebanese University, Beirut, Lebanon.

Open Access   

Published:  Apr 28, 2014

DOI: 10.7324/JAPS.2014.40406
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Abstract

In this work, we studied another species of red algae, Corallina, growing on the Lebanese coast of Batroun. The analysis of trace elements showed that Corallina was rich in K, Ca, Mg, Na, Si, Sr, P and Fe. Corallina was composed of 70.81% of saturated fatty acids, 25.54% of monounsaturated fatty acids and 3.65% of polyunsaturated fatty acids with palmitic acid as the main component. Moreover, the total yield of sulfated galactans and carrageenan was 2.5% and 10%, respectively. Both extracts exhibited anticoagulant effect but sulfated galactans were less potent than carrageenan. Sulfated galactans possessed inhibitory activity as well as bactericidal activity against all Gram-positive strains tested (Enterococcus faecalis ATCC 29212 and Staphylococcus epidermidis CIP 444). But, carrageenan was only able to inhibit the growth of S. epidermidis with a minimal inhibitory concentration (MIC) of 0.325 mg/mL. Furthermore, infrared spectroscopy (IR) revealed that the isolated carrageenan was of Lambda-type. Corallina could therefore be considered as a potential source of bioactive molecules that may be useful for the development of new pharmaceutical agents.


Keyword:     Red algae Corallina sulfated galactans carrageenan antibacterial anticoagulant.

Citation:

Carine Sebaaly, Sahar Kassem, Elena Grishina, Hussein Kanaan, Alaa Sweidan, M. Said Chmit, Hussein M. Kanaan. Anticoagulant and antibacterial activities of polysaccharides of red algae Corallina collected from Lebanese coast. J App Pharm Sci, 2014; 4 (04): 030-037.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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