Research Article | Volume: 4, Issue: 2, February, 2014

Synthesis of Some Novel Heterocyclic 1,2,4-triazolo [3,4-b][1,3,4] Thiadiazole Derivatives as Possible Antimicrobial Agents

Jagdish K. Sahua Swastika Gangulyb Atul Kaushika   

Open Access   

Published:  Feb 27, 2014

DOI: 10.7324/JAPS.2014.40214
Abstract

A series of 6-aryl-3- (3,4–dialkoxyphenyl) -[1,2,4]triazole [3,4-b][1,3,4] thiadiazole (7a-7o) were synthesized by condensing 4-amino-5-(3,4-dialkoxyphenyl)-4H-[1,2,4]- triazole-3-thiol (6) with various aromatic carboxylic acids in the presence of phosphorous oxychloride through one-pot reaction. The structures of these newly synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral studies. All the synthesized compounds were screened for their antimicrobial activity against a variety of microorganisms.


Keyword:     Fused heterocyclesTriazolothiadiazolesAntibacterial activityAntifungal activity.


Citation:

Jagdish K. Sahu, Swastika Ganguly, Atul Kaushik. Synthesis of Some Novel Heterocyclic 1,2,4-triazolo [3,4-b][1,3,4] Thiadiazole Derivatives as Possible Antimicrobial Agents. J App Pharm Sci, 2014; 4 (02): 081-086.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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