Research Article | Volume: 3, Issue: 11, November, 2013

Efficacy of 5-(2-aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles as antibacterial and antifungal agents

Bushra Begum A ,  Noor Fatima Khanum,  Naveen P,  Lakshmi Ranganatha V,  Asha MS and Shaukath Ara Khanum   
Bushra Begum A1 & 2, Noor Fatima Khanum3, Naveen P1, Lakshmi Ranganatha V1, Asha MS1 and Shaukath Ara Khanum1

1Department of Chemistry, Yuvaraja’s college, University of Mysore, Mysore Karnataka, India.

2Department of Chemistry, D.Banumaih’s P U Science College, Mysore, Karnataka, India.

3Department of Food Science and Nutrition, Maharani’s Science College for Women, Mysore, Karnataka, India.

Open Access   

Published:  Nov 29, 2013

DOI: 10.7324/JAPS.2013.31119
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Abstract

Research and development of potent and effective antimicrobial agents represent one of the most important advances in therapeutics; the main aim of these efforts is not only control the serious infections, but also prevention and treatment of some infectious complications of other therapeutic modalities. A series of 5-(2-aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles were screened for their antibacterial and antifungal activities. Anti-bacterial activity against B. cereus, S. aureus, B. subtilis, S. aureus (MRSA), E. aerogenes, M. luteus, K. pneumonia, P. aeruginosa, S. typhimurium, E. coli, paratyphi-B, P. vulgaris bacterial strains and anti-fungal activity against C. albicans, A.niger, F.solani, A.flavus, B.cinerea, C.krusei, M. pachydermatis, C.parapsilosis, F.moniliforme, C.gloeosporioides fungal strains were carried out. The bioassays indicated that most of the synthesized compounds showed potential antibacterial and anti-fungal activity.


Keyword:     1 3 4-oxadiazoles Antibacterial assay Antifungal activity.

Citation:

Bushra Begum A, Noor Fatima Khanum, Naveen P, Lakshmi Ranganatha V, Asha Ms and Shaukath Ara Khanum., Efficacy of 5-(2-aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles as antibacterial and antifungal agents. J App Pharm Sci, 2013; 3 (11): 105-109.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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