Research Article | Volume : 1 Issue : 1, March 2011

Design and development of Orally Disintegrating Tablets of Famotidine Prepared by Direct Compression Method Using Different Superdisintegrants

Mahaveer Pr. Khinchi M.K.Gupta Anil Bhandari Natasha Sharma Dilip Agarwal   

Open Access   

Abstract

Orally disintegrating tablets (ODT) are gaining popularity over conventional tablets due to their convenience in administration and suitability for patients having dysphagia. Moreover no water is required for swallowing the tablets and hence suitable for geriatric, pediatric and traveling patients. Super disintegrants (such as Ac-Di-Sol, Crospovidone, sodium starch glycolate), Diluents (Dibasic calcium phosphate) along with sweetening agent (aspartame) were used in the formulation of tablets. The tablets were evaluated for hardness, friability, water absorption ratio, in-vitro disintegration time (DT), in-vitro disintegration time in oral cavity and in vitro drug release. Using the same excipients, the tablets were prepared by direct compression and were evaluated in the similar way. Maximum drug release and minimum DT were observed with Crospovidone excipient prepared by direct compression.


Keyword:     Orally disintegrating tablets Ac-Di-Sol Crospovidone Dibasic calcium phosphate.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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