Research Article | Volume : 1 Issue : 1, March 2011

Spectrophotometric Simultaneous Determination of Hydrochlorothiazide and Telmisartan in Combined Dosage Form

Rekha Gangola,  Sunil Kaushik,  Paras Sharma   
Rekha Gangola1, Sunil Kaushik1, Paras Sharma2

1Gyani Inder Singh Institute of Professional Studies Dehradun, India.

2Nagaji Institute of Pharmaceutical Science Gwalior, India.

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Abstract

Simple, sensitive, specific and economic spectrophotometric method was developed and validated for simultaneous quantitation of Hydrochlorothiazide and Telmisartan in tablet dosage form. New method based on the simultaneous estimation of drugs in a binary mixture without previous separation was developed. In simultaneous equation method, Hydrochlorothiazide and Telmisartan were quantified using their absorptivity values of at selected wavelengths, viz., 273 nm and 295 nm respectively. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The simultaneous equation method permits simple, rapid and direct determination of Hydrochlorothiazide and Telmisartan in commercially available tablet dosage form without previous separations and can therefore be used for routine analysis of both drugs in quality control laboratories.


Keyword:     Telmisartan Hydrochlorothiazide Vierodt’s method.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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