Microwave assisted synthesis of 3-α-carboxy ethylrhodanine derivatives and their in vitro antibacterial activity

A series of 5-benzylidene-3-α-carboxy ethylrhodanine derivatives (3a-m) were synthesized using 3-α-carboxy ethylrhodanine with various substituted aromatic aldehydes in anhydrous sodium acetate in glacial acetic acid by the knoevenagal condensation under microwave irradiation. The compounds synthesized within short time 10-15 min and in good yields. All the compounds characterized by IR, UV, 1H & 13C-NMR and MS spectral data and studied in vitro antibacterial activity.