Research Article | Volume: 3, Issue: 6, June, 2013

Sunscreen Activity of α -mangostin from the Pericarps of Garcinia mangostana

Liandhajani Maria Immaculata Iwo Sukrasno Andreanus A. Soemardji Muhammad Hanafi   

Open Access   

Published:  Jun 27, 2013

DOI: 10.7324/JAPS.2013.3610
Abstract

A sunscreen active compound has been isolated from the ethanol extract of Garcinia mangostana Linn (Clusiaceae). The ethanol extract was fractionated by liquid liquid extraction with n-hexane, methylene chloride and ethyl acetate, followed by further fractionation and purification using column chromatography on silica gel and gradient elution with combinations of n-hexane and ethyl acetate. Isolation and fractionation was guided by sunscreen activity assay. One of the active compounds was identified as αmangostin based on LC-MS and NMR Spectroscopy. The SPF value of the isolated α –mangostin at 50 and 100 ppm were 21.76 and 37.18, respectively and were much higher than the SPF values of the fractions obtained by liquid-liquid extraction.


Keyword:     α-mangostin Garcinia mangostana Linn sun protector factor (SPF).


Citation:

Liandhajani, Maria Immaculata Iwo, Sukrasno, Andreanus A. Soemardji, Muhammad Hanafi., Sunscreen Activity of α -mangostin from the Pericarps of Garcinia mangostana Linn Liandhajani, Maria Immaculata Iwo, Sukrasno, Andreanus A. Soemardji, Muhammad Hanafi. J App Pharm Sci, 2013; 3 (06): 070-073.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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