Research Article | Volume : 1 Issue : 5, July 2011

Formulation and evaluation of Paclitaxel loaded PSA-PEG nanoparticles

Rajat Sharma Mohd Yasir Sanjay Bhaskar Mohd Asif   

Open Access   

Abstract

The main objective of this study was to prepare and evaluate PSA-PEG nanoparticles containing paclitaxel as a model drug by nanoprecipitation method. The influence of different experimental parameters on the particles size, entrapment efficiency, percent drug released etc was evaluated. SEM indicated that nanoparticles have discrete spherical structure without aggregation. The average particle size was found to be 123 -405 nm. The particle size of nanoparticles increases gradually with PSA-PEG polymer concentration. The drug content of nanoparticles also increases with increasing polymer concentration up to particular value. The in-vitro drug release behavior from all drug loaded batches was found to be zero order and provided sustained release over a period of 24 hours. Nanoparticles were stored at different temperatures and humidity as per ICH guidelines to check the stability.


Keyword:     Nanoparticles PSA-PEG Paclitaxel Nanoprecipitation


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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