Research Article | Volume: 3, Issue: 5, May, 2013
Research Article | Volume: 3, Issue: 5, May, 2013
A new, simple, sensitive luminescence method for the determination of drotaverine hydrochloride is developed and validated. The Drotaverine hydrochloride can remarkably quench the luminescence intensity of the Tb3+ ion in terbium complex with 1-bythyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid-(4-methyl-pyridin-2-yl)-amide (R) in aqueous solutions containing urotropine buffer (pH 7.5) at λex=317 nm and λem=545 nm. Under optimal conditions, the quenching of luminescence intensity is directly proportion to the concentration of Drotaverine hydrochloride in the range of 0.5-300 μg/mL and detection limit is 0.16μg/mL. This method was applied for the determination of Drotaverine hydrochloride in tablets “No-spa”.
Alla Yegorova, Inna Leonenko, Daria Aleksandrova, Yuliya Scrypynets, Aleksandra Aleksandrova., Determination of drotaverine hydrochloride in dosage forms by its quenching effect on the luminescence of terbium complex. J App Pharm Sci, 2013; 3 (05): 006-011.
Year
Month
High Performance Liquid Chromatographic Determination of the Ternary Mixture of Caffeine, Dipyrone and Drotaverine Hydrochloride in Tablet Dosage Form
Evaluation of Shampoos Containing Silicone Quaternary Microemulsion