Research Article | Volume: 3, Issue: 5, May, 2013

Determination of drotaverine hydrochloride in dosage forms by its quenching effect on the luminescence of terbium complex

Alla Yegorova Inna Leonenko Daria Aleksandrova Yuliya Scrypynets Aleksandra Aleksandrova   

Open Access   

Published:  May 30, 2013

DOI: 10.7324/JAPS.2013.3502
Abstract

A new, simple, sensitive luminescence method for the determination of drotaverine hydrochloride is developed and validated. The Drotaverine hydrochloride can remarkably quench the luminescence intensity of the Tb3+ ion in terbium complex with 1-bythyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid-(4-methyl-pyridin-2-yl)-amide (R) in aqueous solutions containing urotropine buffer (pH 7.5) at λex=317 nm and λem=545 nm. Under optimal conditions, the quenching of luminescence intensity is directly proportion to the concentration of Drotaverine hydrochloride in the range of 0.5-300 μg/mL and detection limit is 0.16μg/mL. This method was applied for the determination of Drotaverine hydrochloride in tablets “No-spa”.


Keyword:     Drotaverine hydrochloride luminescence intensity q


Citation:

Alla Yegorova, Inna Leonenko, Daria Aleksandrova, Yuliya Scrypynets, Aleksandra Aleksandrova., Determination of drotaverine hydrochloride in dosage forms by its quenching effect on the luminescence of terbium complex. J App Pharm Sci, 2013; 3 (05): 006-011.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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