Published:  Apr 27, 2013DOI: 10.7324/JAPS.2013.3422
Atherosclerosis is complex disease and the underlying cause of heart attack, stroke and peripheral vascular disease. It is the main cause of morbidity and mortality worldwide, characterized by an excessive inflammatory, fibro fatty, proliferative response to damage of the artery wall. The present study was designed to evaluate the cardioprotective role of Justicia tranquebareinsis Linn. leaf extract on isoproterenol induced myocardial infarction in Wistar albino rats. The rats were divided into five groups of six animals each. Group I served as a normal control, Group II rats were administered isoproterenol (20mg/kg, s.c) at the end of experimental period on the29th and 30th days. Group III and IV were pretreated with Justicia tranquebareinsis Linn. leaf extract (100 mg/kg, 200mg/kg ,respectively) for a period of 28 days and received a subcutaneous injection of isoproterenol (20mg/kg, b.w)at the end of experimental period for 2 consecutive days. Group V received aqueous extract of Justicia tranquebariensis Linn 200mg/kg b.w for 28 days. After the experimental period, blood was collected and serum was separated and used for the estimation of protein, cholesterol, triglycerides, phospholipids, and lipoproteins and the assay of marker enzymes. The heart homogenate was used for the assay lipid profile. Isoproterenol induced rats showed significant increase in the levels of triglycerides, total cholesterol and phospholipids in both serum and heart homogenate. A rise in the levels of LDL, VLDL with significant decrease in the level of HDL was also observed in the serum of isoproterenol-intoxicated rats. Significant increase in the level of myocardial marker enzymes (CK, LDH, ALT and AST) in serum was noted. The LDH & CK levels were low in the heart tissue. Oral administration of aqueous leaf extract of Justicia tranquebariensis Linn. (100 and 200mg/kg) to isoproterenol-induced rats daily for a period of 28 days proved the protective role of the aqueous extract of Justicia tranquebariensis Linn. The levels of the biochemical parameters in the plant treated groups were nearly the same as that of the normal control.
Radhika J, Sathya Surya, Jothi G, Japasheba Jl., Cardioprotective Role of Justicia Traquebareinsis linn. Leaf Extract in Isoproterenol Induced Myocardial Infarction in Albino Rats. J App Pharm Sci, 2013; 3 (04): 124-128.
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