Research Article | Volume: 3, Issue: 3, March, 2013

Synthesis and Antihypertensive Activity of Some Quinazoline Derivatives

Harsha U. Patel Ravi S. Patel Chhaganbhai N. Patel   

Open Access   

Published:  Mar 28, 2013

DOI: 10.7324/JAPS. 2013.30332

Quinazoline derivatives have been very well known for Antihypertensive activity. Seven new Quinazoline derivatives are synthesized by three steps. Purity of compound is checked by TLC monitoring. All synthesized compounds are confirmed by UV, IR, Mass and H1NMR. All synthesized compound were screened for α1-adrenergic receptor blocking activity. Amongst all synthesized compounds 4a & 4e showed better activity.

Keyword:     Quinazolin-4-(3H)-one α1-adrenergic recep


Harsha U. Patel, Ravi S. Patel, Chhaganbhai N. Patel, Synthesis and Antihypertensive Activity of Some Quinazoline Derivatives . J App Pharm Sci. 2013; 3 (03): 171-174.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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