Research Article | Volume: 3, Issue: 3, March, 2013

Preliminary in vivo evaluation of anti-inflammatory activities of aqueous and ethanolic whole plant extracts of Phyllanthus fraternus on Carrageenan-induced Paw Oedema in Sprague-Dawley Rats

Oseni L.A. Amiteye D. Antwi S. Tandoh M. Aryitey G.M.   

Open Access   

Published:  Mar 28, 2013

DOI: 10.7324/JAPS.2013.30312
Abstract

Medicinal plants represent potential sources for the discovery of new anti-inflammatory agents. Aqueous and ethanolic whole plant extracts of Phyllanthus fraternus were evaluated in vivo for their anti-inflammatory activities on carrageenan-induced paw oedema in Sprague-Dawley rats. The extracts were also screened for phytochemicals. Some of the phytochemicals found in the extracts have previously been implicated as anti-inflammatory agents. The LD50 of both extracts was investigated and found to be greater than 5000mg/kg. The extracts at doses 100mg/kg and 200mg/kg showed modest anti-inflammatory activity in a dose dependent manner. The aqueous extract demonstrated better inhibition of paw oedema compared with the ethanolic extract at 200mg/kg after 4hrs. The activity of the standard drug, indomethacin at 25.0 mg/kg was significantly higher (p


Keyword:     In vivo anti-inflammatory Phyllanthus frat


Citation:

Oseni L.A. Amiteye D., Antwi S., Tandoh M., Aryitey G.M., Preliminary in vivoevaluation of anti-inflammatory activities of aqueous and ethanolic whole plant extracts of Phyllanthus fraternus on Carrageenan-induced Paw Oedema in SpragueDawley Rats. J App Pharm Sci. 2013; 3 (03): 062-065.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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