Research Article | Volume: 7, Issue: 7, July, 2017

Clinical Evaluation of the Safety and Effectiveness of Adutwumwaa Malamix: A Polyherbal Product for the Treatment of Uncomplicated Malaria in Ghana

Andrews W. Tetteh Merlin L. Mensah Kwame O. Boadu Kwesi P. Thomford Michael O. Agyemang Kofi Annan Rita Dickson Abraham Y. Mensah Isaac K. Amposah Edmund Ekuadzi Emmanuel D. J. Owusu-Ansah   

Open Access   

Published:  Jul 30, 2017

DOI: 10.7324/JAPS.2017.70706
Abstract

Antimalarial medications remain one of the major interventional tools for the global malaria control efforts. One of the most popular Ghanaian herbal antimalarial agent is the product sold under the trade name ‘Adutwumwaa malamix’. This product is registered with the Food and Drugs Authority (FDA) of Ghana as treatment of uncomplicated malaria. In this study, the safety and effectiveness of the product ‘Adutwumwaa malamix’ for the treatment of uncomplicated malaria was clinically evaluated based on disease-oriented and patient-oriented evidence. A total of 42 subjects were recruited for the study. Complete cure was achieved for 35 (83.33%) of participants by day 7 of the study. Partial efficacy was also achieved for 7 (16.66%) of subjects. Patient reported symptoms such fever, chills and abdominal pains were also significantly improved by day 7 and absent by day 28. The safety parameters assessed did not show any clinically significant change among the study population during treatment. The outcome of the study indicates that the Ghanaian herbal antimalarial agent ‘Adutwumwaa malamix’ may be an effective herbal treatment for the management of uncomplicated malaria.


Keyword:     Adutwumwaa malamix Anthocleista nobilis Phyllanthus fratenus polyherbal antimalarial safety and effectiveness Vitex grandifolia.


Citation:

Tetteh AW, Mensah MLK, Boadu KO, Thomford KP, Agyeman MO, Annan K, Dickson RA, Mensah AY, Amponsah IK, Ekuadzi E, Owusu-Ansah ED. Clinical Evaluation of the Safety and Effectiveness of Adutwumwaa Malamix: A Polyherbal Product for the Treatment of Uncomplicated Malaria In Ghana. J App Pharm Sci, 2017; 7 (07): 040-045.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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