Research Article | Volume: 3, Issue: 2, February, 2013

Effect on Hepatic Parameters and Hepatocytes following administration of antihypertensive, hypolipidemic and hypoglycemic drugs in combination (Part II)

Afshan Siddiq and Rafeeq Alam Khan   

Open Access   

Published:  Feb 27, 2013

DOI: 10.7324/JAPS.2013.30218
Abstract

Liver damage is the serious additive effect of drugs used for the treatment of patients suffers from diabetes, hypertension and hyperlipidemia. In continuation of our previous published research the present study is done to evaluate the toxic effects of combination of drugs prescribed for above stated diseases. Combinations of drugs were given to rabbits for the period of two months and their effects on liver function tests were observed. As compared to control rabbits, the combination Acarbose, Lisinopril and Atorvastatin showed increased Glutamic-Pyruvic Transaminase (GPT), Alkaline Phosphatase (ALP) and Gamma glutamyl transferase (γ-GT) (p <0.005), while the animals received combination Metformin, Amlodipine and Atorvastatin showed significant decrease in Alkaline Phosphatase (ALP) and Gamma glutamyl transferase (γ-GT) (p <0.005). The study proved increased in toxic effect of these drugs on hepatocytes when above combination are given, however, Glibenclamide, Losartan and Atorvastatin seems to be safer then others combinations given.


Keyword:     Multiple drugs hypoglycemia hyperlipidemia antihy


Citation:

Afshan Siddiq and Rafeeq Alam Khan. Effect on Hepatic Parameters and Hepatocytes following administration of antihypertensive, hypolipidemic and hypo-glycemic drugs in combination (Part II). J App Pharm Sci. 2013; 3 (02): 105-108.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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