Published:  Jan 28, 2013DOI: 10.7324/JAPS.2013.30102
The new generation of lipid nanoparticles with solid matrix are the NLC (Nanostructured lipid carriers), and these nanoparticles show increased chemical stability of drug, film formation, controlled occlusion, increased skin hydration, the bioavailability of the active skin is improved, increase the physical stability of lipid nanoparticles in topical formulations and lower toxicity. The NLC were produced by the technique of High Pressure Homogenization (HPH). The Accelerated Stability Test, also known as Normal Stability or exploratory, aims to provide data to predict product stability, shelf life and formulation compatibility with the packaging material. Therefore, this study aims: to evaluate the normal stability under varying conditions of temperature and luminosity over time as their physical and chemical characteristics in cosmetic formulation containing ursolic acid in free and nanoparticle forms. Based on the results, the ursolic acid in the nanostructured lipid carrier form achieved a better physical and chemical stability compared to ursolic acid in the free form in both variation of the viscosity and pH.
Almeida, Mariana Mandelli; Bou-Chacra, Nádia A; Conte, Juliana Denise; Kaneko, Telma Mary; Baby, André Rolim; Velasco, Maria Valéria Robles. Evaluation of physical and chemical stability of nanostructured lipid carries containing ursolic acid in cosmetic formulation. J App Pharm Sci. 2013; 3 (01): 005-008.
601 Absract views 20 PDF Downloads 621 Total views
Anxiolytic effect of chronic administration of ursolic acid in ratsSudhakar Pemminati, Gopalakrishna HN, Venkatesh.V, Amritha Rai,Sowjanya Shetty, Amrita Vinod, Preethi G Pai, Ashok K Shenoy
Formulation and evaluation of Salbutamol sulphate microspheres by solvent evaporation methodV.V Prasanth, Akashmoy Chakraborty, Sam T Mathew, Rinku Mathappan, V. Kamalakkannan
Efficacy and In Vitro Cytotoxicity of Nanostructured Lipid Carriers for Paclitaxel Delivery