Research Article | Volume: 2 Issue: 12, December, 2012

Hepatoprotective and Antioxidant Activity of Ethanol Extract of Cynoglossum zeylanicum (Vahl ex Hornem) Thurnb ex Lehm in CCl4 Treated Rats

Anitha M,  Daffodil E.D.,  Muthukumarasamy S. and Mohan V.R.   
Anitha M1, Daffodil E.D.2, Muthukumarasamy S.3 and Mohan V.R.2

1Department of Botany, Sri Parasakthi College for Women, Courtallum, Tamil Nadu.

2Ethnopharmacology Unit, Research Department of Botany, V. O. Chidambaram College, Tuticorin, Tamil Nadu.

3Department of Botany, Sri K.G.S. Arts College Srivaikuntam, Tamil Nadu.

Open Access    DOI: 10.7324/JAPS.2012.21219

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Abstract

This study was designed to evaluate the hepatoprotective and antioxidant effect of ethanol extract of whole plant of Cynoglossum zeylanicum on CCl4 induced hepatotoxicity in rats. Activities of liver marker enzymes, SGOT, SGPT and ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins at an oral dose of ethanol extract of Cynoglossum zeylanicum (50, 100 and150mg/kg) showed a significant hepatoprotective effect. Regarding antioxidant activity, ethanol extract of Cynoglossum zeylanicum exhibited a significant effect showing increasing levels of SOD, CAT, GPx, GSH and GRD by reducing malondialdehyde (MDA) levels.


Keyword:     Hepatoprotective activityAntioxidantCCl4BilirubinMDAGGT.

Citation:

Anitha M., Daffodil E.D., Muthukumarasamy S., and Mohan V.R., Hepatoprotective and Antioxidant Activity of Ethanol Extract of Cynoglossum zeylanicum (Vahl ex Hornem) Thurnb ex Lehm In CCl4 -Treated Rats J App Pharm Sci. 2012; 2 (12): 099-103.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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