Research Article | Volume: 2 Issue: 12, December, 2012

Antimicrobial and Preliminary Phytochemical studies of Methanol Extract of Root Bark of Crossopteryx febrifuga (Rubiaceae)

Halilu M.E A. Abubakar Garba M.K and Isah A. A   

Open Access    DOI: 10.7324/JAPS.2012.21212


Crossopteryx febrifuga is one of the useful plants used in Hausa traditional medicine in North Western Nigeria. It belongs to the family Rubiaceae. The phytochemical studies of the root bark of the plant was carried out using standard procedure. The was found tocontain: steroids, flavonoids, terpenoids, anthraquinones, cardiac glycosides, tannins, alkaloids and saponnins. The antimicrobial activity screening was carried out using both bacterial and fungal strains. The bacterial strains include: Pseudomonas aeruginosa, Staphylococcus aureus, Eschericia coli. The fungal strains Include: Aspergillus fumigatus, Candida albicans, Aspergillus flavus and Aspergillus niger. In general, the extract showed considerable activity on the bacterial species. It inhibited the growth of both gram positive and gram negative microorganism with zones of inhibition ranging from 7- 23 mm at concentrations of 50 µg/ml, 100 µg/ml and 200 µg/ml. The plant extract did not show significant activity on fungal strains. It inhibited the growth of Aspergillus fumigatus at 400 µg/ml and 500 µg/ml which produced zones of inhibition of 8 mm and 12 mm respectively at the stated concentration. It can be concluded that the activity showed by the methanolic extract of the plant is as a result of the phytochemicals present in the plant.

Keyword:     Antimicrobial Phytochemical Studies Crossopteryx febrifuga Zone of Inhibition MIC and MBC.


Halilu M.E., A. Abubakar., Garba M.K. and Isah A.A., Antimicrobial and Preliminary Phytochemical studies of Methanol Extract of Root Bark of Crossopteryx febrifuga (Rubiaceae).J App Pharm Sci. 2012; 2 (12): 066-070.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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