Research Article | Volume: 2 Issue: 11, November, 2012

Evaluation of gastro-protective effect of the hydro-alcoholic extract of Juglans regia. L leaves in experimental animals

Kumaraswamy Dabburu Suresh Babu Kondaveeti Sarath Babu.K   

Open Access    DOI: 10.7324/JAPS.2012.21114

Abstract

The aim of our study was to evaluate the gastro protective effect of aqueous extract of Juglans regia.L leaves in albino rats. Albino rats of wistar variety weighing 140-165gms were used in the experiment. The sexes were evenly divided into different treatment groups. The aqueous leaf extract of Juglans regia.L was investigated for its anti- ulcer activity against pylorus ligation, aspirin induced and ethanol induced gastric ulcer in rats at 500mg/kg body weight p.o. Histopathological assessment of rat stomach was carried out. A significant reduction (p<0.01) in ulcer index was seen in leaf extracts of Juglans regia.L treated rats of pylorus ligation, aspirin induced and ethanol induced gastric ulcer models. The gastro protective effect was further confirmed by histopathological examination of rat stomach. Thus the present study concludes the Juglans regia.L leaf extract having potential gastro protective effect in the three models tested.


Keyword:     Juglans regia. L pylorus ligation aspirin ethanol.


Citation:

Kumaraswamy Dabburu, Suresh Babu Kondaveeti, Sarath Babu.K. , Evaluation of Gastroprotective Effect of the Hydro Alcholic Extract of Juglans Regia.L Leaves In Experimental Animals.J App Pharm Sci. 2012; 2 (11): 079-083.

Source of support: - Nil,

Conflict of Interest: None declared

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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