Research Article | Volume: 2 Issue: 10, October, 2012

Design and Characterization of Nanostructure Topical Gel of Betamethasone Dipropionate for Psoriasis

Md. Sarfaraz Alam Md. Sajid Ali Nawazish Alam Md Intakhab Alam Tarique Anwer Faisal Imam Md. Daud Ali Masoom Raza Siddiqui Md. Shamim   

Open Access    DOI: 10.7324/JAPS.2012.21029

Abstract

Psoriasis is a chronic T lymphocyte mediated autoimmune inflammatory disorder that affects the skin, joints, and tendons. Betamethasone dipropionate (BD) has anti-inflammatory, immunosuppressive,and antiproliferative activity. The aim of this study was to investigate and evaluate a nanoemulsion topical gel of betamethasone dipropionate. For the preparation of nanoemulsion eucalyptus oil and babchi oil was taken. Nanomulsions were prepared by aqueous phase-titration method. Pseudoternary phase diagrams were constructed for the identification of nanoemulsion existence zones. Prepared nanoemulsions were subjected to different thermodynamic stability tests and characterized for droplet size, viscosity and refractive index. In vitro skin permeation of betamethasone dipropionate through rat abdominal skin was determined by the Franz diffusion cell. The prepared nanoemulsion gel is a potential vehicle for improved topical delivery of BD for better treatment of psoriasis.


Keyword:     Anti-inflamatory effects betamethasone dipropionate psoriasis nanoemulsion transmission electron microscopy histopathology.


Citation:

Md. Sarfaraz Alam, Md. Sajid Ali, Nawazish Alam, Md Intakhab Alam, Tarique Anwer, Faisal Imam, Md. Daud Ali, Masoom Raza Siddiqui, Md. Shamim. Design and Characterization of Nanostructure Topical Gel of Betamethasone Dipropionate for Psoriasis . J App Pharm Sci. 2012; 2(10): 148-158.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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