Research Article | Volume: 2 Issue: 10, October, 2012

Effect of Recrystallization on the Pharmaceutical Properties of Valsartan for Improved Therapeutic Efficacy

Buchi N. Nalluri Ramya Krishna M Rao TP Peter A. Crooks   

Open Access    DOI: 10.7324/JAPS.2012.21025


Valsartan (VAL) is a potent, highly selective and orally active antihypertensive drug and is poorly soluble in aqueous fluids, especially in gastric fluids, and its absorption is thus dissolution rate limited. In the present research work an attempt has been made to improve the aqueous solubility of VAL by the recrystallization of VAL from a variety of different organic solvents, and evaluating the recrystallized VAL products for its physicochemical characteristics and in-vitro dissolution properties. The water solubility of methanol (MET), ethanol (ETH), isopropanol (ISP) and acetonitrile (AN) recrystallized products of VAL is significantly higher when compared to untreated VAL. Physicochemical characterization techniques like scanning electron microscopy, differential scanning calorimetry, powder X-RD reveal the change in crystallinity of VAL with recrystallized products and hence the increase in the solubility and superior dissolution properties when compared to the untreated VAL.

Keyword:     Valsartanrecrystallizationphysicochemcial characterizationdissolution studies


Buchi N. Nalluri, Ramya Krishna M, Rao TP, Peter A. Crooks. Effect of Recrystallization on the Pharmaceutical Properties of Valsartan for Improved Therapeutic Efficacy. J App Pharm Sci. 2012; 2(10): 125-131.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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