Research Article | Volume: 2 Issue: 10, October, 2012

Study of Binary and Ternary Solid Dispersion of Spironolactone Prepared By Co-Precipitation Method for the Enhancement of Oral Bioavailability

Mohammad Fahim Kadir,  Md. Rashedul Alam,  Akib Bin Rahman,  Yeakuty Marzan Jhanker,  Tahiatul Shams,  Rajibul Islam Khan   
Mohammad Fahim Kadir1, Md. Rashedul Alam2, Akib Bin Rahman3, Yeakuty Marzan Jhanker1, Tahiatul Shams1, Rajibul Islam Khan2

1Department of Pharmacy, University of Asia Pacific, Dhaka-1209, Bangladesh.

2Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.

3Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.

Open Access    DOI: 10.7324/JAPS.2012.21023

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Abstract

The study was designed to formulate novel spironolactone, a BCS class II drug loaded solid dispersion system (SDs) with improved dissolution rate. For this purpose binary and ternary solid dispersion were prepared by co-precipitation method using Poloxamer-407 only and mixture of poloxamer-407 with a second polymer such as HPMC 6cps, HPC, Kollicoat IR, Kollidon VA 64 respectively. To prepare binary SDs poloxamer 407 was used in three concentrations: 33%, 50% and 66.67% wt/wt of total SDs, whereas in case of ternary SDs, poloxamer 407 was used at 15%, 25% 35% wt/wt of the total SDs content and the concentration of the second polymer is maintained at fixed amount (1gm). In vitro dissolution study was carried out in a USP type II dissolution apparatus in 0.1 N hydrochloric acid solution for 1 hour. Release property of spironolactone from two different SDs was examined. Both the systems showed improved release profile compared with pure spironolactone powder. Enhanced release of spironolactone from the optimized SDs was characterized in light of cumulative percent release, % release after 5 min of dissolution and release rate of the drug from different SDs. When the amount of carriers increased with a decrease in drug content, the release of spironolactone was elevated. And it was found that almost two fold increase in the release of spironolactone while 66.67% poloxamer was used.


Keyword:     Solid dispersionSpironolactoneCo-precipitationpoloxamer-407Dissolution.

Citation:

Mohammad Fahim Kadir. Md. Rashedul Alam, Akib Bin Rahman, Yeakuty Marzan Jhanker, Tahiatul Shams, Rajibul Islam Khan, Study of Binary and Ternary Solid Dispersion of Spironolactone Prepared by Co-Precipitation Method for the Enhancement of Oral Bioavailability. J App Pharm Sci. 2012; 2 (10): 117-122.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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