Research Article | Volume: 2 Issue: 10, October, 2012

Synthesis of quinolines and their In vitro antioxidant activities under solvent free conditions by using the SiO2-Zn-MgO as a novel and reusable catalyst

M. Brahmayyaa,  B. Venkateswara raoa,  U. Viplavaprasadb,  M.V. Basaveswara Raoc,  K. Raghu Babua,  B. Kishore babua,  K. Rajkumara,  Ch. Praveenb,  N. Giribabud,  M. Vijayaa,  Ch. V. Padmaraoa,  N. Srinivasa Raod   
M. Brahmayyaa, B. Venkateswara raoa, U. Viplavaprasadb, M.V. Basaveswara Raoc, K. Raghu Babua, B. Kishore babua, K. Rajkumara, Ch. Praveenb, N. Giribabud, M. Vijayaa, Ch. V. Padmaraoa, N. Srinivasa Raod

aDepartment of Engineering Chemistry, Andhra University, Visakhapatnam-530003, India.

bDepartment of Organic Chemistry and FDW, Andhra University, Visakhapatnam-530003, India.

cDepartment of Chemistry, Krishna University, Machilipatnam – 521 001, India.

dPharmacology Division, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India.

Open Access    DOI: 10.7324/JAPS.2012.21008

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Abstract

The present study was aimed to determine a novel route of synthesis of quinolines and their in vitro antioxidant activities. Synthesis of quinolines is simple, economic, effective and an easy way process has been developed by using the SiO2–Zn-MgO as a novel catalyst. The quinolines antioxidative potential was evaluated using 1,1-Diphenyi-2-Picrylhydrazyl (DPPH), superoxide radical, hydroxyl radical, and hydrogen peroxide radical assay by in vitro methods. Quinolines exhibited highest level of antioxidant activities, and therefore it could be used as antioxidant that may have potential benefits in health and disease management.


Keyword:     Novel catalystSolvent freeQuinolineIn vitroantioxidant

Citation:

M. Brahmayya, B. Venkateswara rao, U. Viplavaprasad, M.V. Basaveswara Rao, K. Raghu Babu, B. Kishore babu, K. Rajkumar, Ch. Praveen, N. Giribabu, M. Vijaya, Ch. V. Padmarao, N. Srinivasa Rao. Synthesis of quinolines and their In vitro antioxidant activities under solvent free conditions by using the SiO2–Zn–MgO as a novel and reusable catalyst. J App Pharm Sci. 2012; 2 (10): 041-044.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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