Research Article | Volume: 2 Issue: 9, September, 2012

The Effects of Noni (Morinda citrifolia L.) Fruit Juice on Cholesterol Levels: A Mechanistic Investigation and an Open Label Pilot Study

Afa K. Palu Ashley Brown Shixin Deng Norman Kaluhiokalani Brett. J. West   

Open Access    DOI: 10.7324/JAPS.2012.2905

Abstract

The traditional usage of noni fruit did not include any claims for lowering cholesterol levels in humans. However, recently a commercial noni fruit juice blend, Tahitian Noni OriginalĀ® Bioactive (TNOB), was shown in a double blind, and placebo control clinical trial to significantly lower cholesterol levels in current smokers. But, its effect on cholesterol levels of nonsmokers with normal cholesterol levels, and its mechanisms of action, has not been fully elucidated. The current study evaluates the effects of various noni preparations (TNOB, NFJC (noni fruit juice concentrates), NFJME (noni fruit juice methanol extract)) on HMG-CoA Reductase and ACAThepatic/intestine enzymes in vitro. Further, TNOB was evaluated for its potential cholesterol-lowering effects in 10 non-smoking subjects with normal to mild cholesterol levels. TNOB and NFJC both inhibited HMG-CoA Reductase, and ACAT enzymes concentration-dependently in-vitro, and NFJC has a


Keyword:     Noni juiceHMG-CoA ReductaseACAT EnzymesMechanism


Citation:

Afa K. Palu, Ashley Brown, Shixin Deng, Norman Kaluhiokalani, Brett. J. West. The Effects of Noni (Morinda citrifolia L.) Fruit Juice on Cholesterol Levels: A Mechanistic Investigation and An Open Label Pilot Study. J App Pharm Sci. 2012; 2(9): 025-030.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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