Cubic Spline and Determination of Changes in the Solid Dispersion of Cefuroxime Axetil by Using MATLAB Software

Studies in pharmaceutical systems are used to pick up the physicochemical properties of drugs, one of them are solid dispersions requiring a carrier to achieve that purpose. Generally hydrophilic agents are used as a carrier, because they have high hydrophilicity and are used in the pharmaceutical industry as excipients. In this work the Urea merges with Cefuroxime Axetil (CFA) for the formation of three solid dispersions, the antibacterial drug (CFA) is insoluble in water, creating problems of bioavailability in the body. Solid Dispersion of CFA was prepared with a ratio of 1:1, 1:2 and 1:3 using Urea. The study of bioactivity of the solid solutions was performed by Differential Scanning Calorimetry (DSC) and showing that part of CFA is retained in the volume (structure) of Urea and some joins the surface. The data analyzed were for the absorbance of each sample that were applied a cubic interpolation to determine differences between the dispersions by using MATLAB software (V.No. R201 1b).