Amlodipine besylate is a long-acting calcium channel blocker used to treat chronic stable angina, vasospastic angina and hypertension. Amlodipine is a sparingly soluble orally administered drug and the rate of absorption is often controlled by the rate of dissolution. The rate of dissolution will increase by incorporating the drug in a fast dissolving dosage form. An attempt will be made to develop rapidly disintegrating oral tablets of Amlodipine Besylate by direct compression method. In this study, Fast Dissolving Tablet (FDT) was prepared using direct compression method using Crospovidone and Sodium starch glycolate as the super disintegrants. Amongst all formulations, formulation F3 prepared by a combination of both Crospovidone and Sodium starch glycolate showed least disintegrating time, and faster dissolution of 87%. Combination of super disintegrants were found to be better to formulate fast dissolving tablets of Amlodipine besylate.
375 Absract views 14 PDF Downloads 389 Total views
Isolation of Mucilage from Cydonia vulgaris Pers. Seeds and its Evaluation as Superdisintegrant
Design and development of Orally Disintegrating Tablets of Famotidine Prepared by Direct Compression Method Using Different SuperdisintegrantsMahaveer Pr. Khinchi, M.K.Gupta, Anil Bhandari, Natasha Sharma, Dilip Agarwal
First step in the assessment of mechanical properties of pure API: production of tablet with minimum addition of excipientNaz Hasan Huda, Yeakuty Marzan Jhanker, Riaz Uddin