Research Article | Volume: 2 Issue: 8, August 2012

Formulation and Characterization of Fast Disintegrating tablets of Amlodipine using Super-disintegrants

Behin Sundara Raj Punitha I.S.R. Suraj Dube   

Open Access    DOI: 10.7324/JAPS.2012.2819

Abstract

Amlodipine besylate is a long-acting calcium channel blocker used to treat chronic stable angina, vasospastic angina and hypertension. Amlodipine is a sparingly soluble orally administered drug and the rate of absorption is often controlled by the rate of dissolution. The rate of dissolution will increase by incorporating the drug in a fast dissolving dosage form. An attempt will be made to develop rapidly disintegrating oral tablets of Amlodipine Besylate by direct compression method. In this study, Fast Dissolving Tablet (FDT) was prepared using direct compression method using Crospovidone and Sodium starch glycolate as the super disintegrants. Amongst all formulations, formulation F3 prepared by a combination of both Crospovidone and Sodium starch glycolate showed least disintegrating time, and faster dissolution of 87%. Combination of super disintegrants were found to be better to formulate fast dissolving tablets of Amlodipine besylate.


Keyword:     Fast Disintegrating tabletCrospovidoneSodium starch glycolateAmlodipine Besylate.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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