Research Article | Volume: 2 Issue: 8, August 2012

Development and In Vitro Investigation of Mucoadhesive Paste with Methylprednisolone Hydrogen Succinate

Vladimira Ivanova,  Bistra Kostova,  Dimitar Rachev   
Vladimira Ivanova, Bistra Kostova, Dimitar Rachev

Faculty of Pharmacy, Medical University, 2 Dunav Str.,Sofia-1000, Bulgaria.

Open Access    DOI: 10.7324/JAPS.2012.2808

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Abstract

Mucoadhesive pastes with Methylprednisolone hydrogen succinate are characterized with pronounced therapeutic activity in treating Pemfigus vulgaris. Two types of Carbomer as drug release carriers were used: Carbopol® 971P NF and Carbopol® 974P NF in concentrations between 27 to 32%. Mucoadhesive pastes were based on paraffin liquid with the use of Magnesium stearate to improve the structural characteristics of the systems. Tests for adhesion, stability and in vitro drug release of developed models of mucoadhesive pastes were carried out. The results obtained show the influence of the type and concentration of polymer used on the adhesion and the rate and degree of drug release. The stability of the developed mucoadhesive pastes was provided by inclusion of 2 wt % magnesium stearate.


Keyword:     Methylprednisolone hydrogen succinate drug delivery systems mucoadhesive paste carbomers.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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