Research Article | Volume: 2 Issue: 8, August 2012

Sunburn (fohia) Healing Effects of Noni: Is it a Mechanism Involving Its Inhibitory Effects on MMP, COX-2 and Cat-G Enzymes?

Afa K. Palu Shixin Deng Brett J. West Jarakae Jensen Rachel A. Sabin   

Open Access    DOI: 10.7324/JAPS.2012.2805


The aim of the present investigation was to evaluate whether extracts and preparations of noni fruit and leaf, a Polynesian traditional herbal medicine, inhibit MMP, COX-2 and Cat-G enzymes in vitro, as its mechanism of action for healing sun-burn known as fohia in Tonga. Noni leaf ethanolic extract (NLEE) inhibited MMP-1, -2, -3, and -9 enzymes concentration dependently with 0.517, 0.234, 0.184, and 0.302 mg/mL IC50, respectively. Noni fruit juice concentrates (NFJC) in 1 and 5 mg/mL concentrations, inhibited MMP-12 enzymes by 102, and 99%, respectively. NFJC and NLEE inhibited Cat-G enzymes concentration-dependently with 0.125,

Keyword:     PhotoprotectionMMP enzymescathepsin Gskin healthphotoagingnoni.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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