Retinoids—A unique ingredient for skin rejuvenation employing novel drug delivery systems

Sneha Jateen Pradhan Ashwin Kuchekar Ashwini Gawade Sushil Kore   

Open Access   

Published:  May 07, 2024

DOI: 10.7324/JAPS.2024.168608
Abstract

Millions of people around the world fall within the age group of 35 and above; having fluctuating lifestyles, increased exposure to blue light, and a faster-depleting ozone layer that enhances entry of UVA and UVB rays in the skin which tends to age faster leading into collagen degradation that results in fine lines and decreased cell senescence. The goal of skin rejuvenation is to have healthy skin. Cosmeceuticals incorporating retinoids have been increasingly used over the past few years to promote collagen synthesis and rejuvenate the skin. Photo-induced and chronological aging processes are decelerated with retinoid application that endorses skin elasticity by free radical neutralization, new cell growth, and blood vessel promotion within the skin to help fight pigmentation and reduce fine lines. Retinoids are commercially available as creams and serums for topical application. Nanotechnology is used in the development of retinoids to counteract adverse reactions like skin irritation and purging to improve its stability, efficacy, and acceptability. Emerging studies on retinoids include formulating them within liposomes, solid lipid nanoparticles, nano-emulgels, and hydrogels. This review details understanding the aging process, the mechanism of action of retinoids to counterfeit aging, and the potential use of nanotechnological delivery in cosmeceuticals.


Keyword:     Photoaging topical systems retinol nanoparticles nanodrug delivery liposomes


Citation:

Pradhan SJ, Kuchekar A, Gawade A, Kore S. Retinoids—A unique ingredient for skin rejuvenation employing novel drug delivery systems. J Appl Pharm Sci. 2024. Online First. http://doi.org/10.7324/JAPS.2024.168608

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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