Research Article | Volume: 2 Issue: 7, July 2012

Development and Validation of Analytical Method for Quantitative Estimation of Miglitol and Metformin in Combined Dosage Form

Sejal R Patel,  Prachi V Kabra,  Ritu V Kimbahune,  Ravikiran Markad,  LVG Nargund   
Sejal R Patel1, Prachi V Kabra1, Ritu V Kimbahune2, Ravikiran Markad1, LVG Nargund1

1Department of Quality Assurance, Nargund college of pharmacy, Dattatreyanagar, II-main, 100ft ring road, BSK III-stage, Bangalore-85, Karnataka.

2Department of Quality Assurance, Al-ameen College of Pharmacy, Hosur Road, Near Lalbagh Main Gate Sudhama Nagar, Bangalore, Karnataka 560 027.

Open Access    DOI: 10.7324/JAPS.2012.2738

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Abstract

A simple, accurate, economical and reproducible UV spectrophotometric method for simultaneous estimation of Miglitol and Metformin in combined tablet dosage form has been developed. The developed method employs multi component spectroscopy using 300nm, 270nm, 240nm and 210nm as wavelengths for estimation. Miglitol and Metformin were found to be linear in the concentration range of 0.2-1.2 µg/ml and 2-12 µg/ml respectively. %Assay was found to be in the range of 99.27 – 99.92% and 99.29 – 99.97% for Miglitol and Metformin respectively. Results of analysis were validated statistically in accordance with ICH guidelines.


Keyword:     MiglitolMetforminMulti Component Spectroscopy.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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