Research Article | Volume : 1 Issue : 5, July 2011

Invitro studies and evaluation of metformin marketed tablets-Malaysia

Arcot Ravindran Chandrasekaran Chan Yoke Jia Choong Sheau Theng Teeba Muniandy Selvadurai Muralidharan Sokkalingam Arumugam Dhanaraj   

Open Access   

Abstract

In this research project, we are assigned a topic to study on the in vitro equivalency evaluation of Metformin tablets. The main focus of this research is to conduct dissolution test on the tablets to determine the compliance with a given official monograph. Dissolution testing is a method for evaluating physiological availability that depends upon having the drug in a dissolved state. The release profiles obtained from in vitro dissolution tests can be used for predicting in vitro in vivo correlation models. In vitro dissolution test is conducted on five different brands of Metformin tablets to evaluate their equivalency. Tablets or capsules taken orally remain one of the most effective means of treatment available. The effectiveness of such dosage forms relies on the drug dissolving in the fluids of the gastrointestinal tract prior to absorption into the systemic circulation. The rate of dissolution of the tablet or capsule is therefore crucial. In this research, our aim is to develop an in vitro test method that fully models the physiological conditions in the GI tract. The dissolution media used closely resembles the GI fluid in the stomach. Simulation of GI pH gradients, peristaltic movement, transit times, biliary and pancreatic secretions and water absorption are examples of features in such dynamic in vitro test model.


Keyword:     Invitro Metformin.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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