Research Article | Volume: 2 Issue: 7, July 2012

Synthesis and biological evaluation of 2,4,5-triphenyl-1H-imidazole-1-yl Derivatives

Shailesh P. Zala,  Badmanaban R.,  Dhrubo Jyoti Sen,  Chhaganbhai N. Patel   
Shailesh P. Zala, Badmanaban R., Dhrubo Jyoti Sen, Chhaganbhai N. Patel

Department of Quality Assurance & Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, India.

Open Access    DOI: 10.7324/JAPS.2012.2732

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Abstract

In the present investigation, our aim of synthesis is to find a molecule having multi drug treatment means the drug which resists the inflammation produce due to microbial infection. So, 2,4,5-triphenyl-1H-imidazole-1-yl derivatives were synthesized and tested for their anti-inflammatory activity in-vitro using Phenylbutazone as a reference drug and antimicrobial activity using clotrimazole and ciprofloxacin as a standard drug. Compound 6b was found to be the most potent derivative of the series.


Keyword:     Triphenyl-ImidazoleAnti-inflammatoryAntimicrobialMulti-drug.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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