Research Article | Volume : 2 Issue : 6, June 2012

Spectrophotometric method of estimation of atorvastatin calcium using sulfo-phospho-vanillinreaction

Shyni Bernard Molly Mathew   

Open Access    DOI: 10.7324/JAPS.2012.2606


A simple and sensitive visible spectrophotometric method has been developed for the determination of Atorvastatin (ATV) in pure form and in tablets using Sulfo-Phospho-Vanillin reagent.The methods is based on the reaction of atorvastatin with sulphuric acid to form carbonium ion,which subsequently react with vanillin phosphate ester and measuring the resulting purple coloured complex at 414 nm. Under the proposed optimum condition, Beer’s law was obeyed at the concentration range of 30-100μg/ml. The result of analysis of tablet was found to be 99.81 %. The good results of recovery studies showed that the co-formulated substances did not interfere with the determination. The method was validated according to ICH guidelines by performing linearity, accuracy, and precision, limits of quantification, limit of detection and selectivity.

Keyword:     AtorvastatinSpectrophotometryTabletsVanillin.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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