Research Article | Volume : 2 Issue : 5, May 2012

Hypoglycemic Activity of Methanolic Extract of Talinum Triagulare Leaves in Normal and Streptozotocin Induced Diabetic Rats

Ravindra Babu. P Rama Rao. D Prasada Rao. M J. V. Krishna Kanth M.Srinivasulu V. Hareesh   

Open Access    DOI: 10.7324/JAPS.2012.2537

Abstract

Talinum Triangulare (Family: Portulacaceae) is an herbaceous perennial plant widely grown in tropical regions as a leaf vegetable with a blood-glucose-lowering effect, but its mechanism of action are still unknown. Here we report a hypoglycemic activity of Methanolic Extract of Talinum Triangulare Leaf (METTL) in healthy, glucose loaded and Streptozotocin (STZ)-induced diabetic rats. Animals either healthy or STZ-induced diabetic show significantly lowered blood glucose levels after 2 weeks of METTL treatment (250 mg/kg), it significantly reduced blood glucose levels compared with that in diabetic control rats. Additionally, the increase in blood glucose levels after administration of glucose (1.2 g/kg) in normal rats is significantly decreased and the oral glucose tolerance (OGTT) of STZ-induced diabetic rats is largely improved by METTL treatment. However, co-administration of METTL with glipizide, an oral hypoglycemic drug, it produces synergistic effect. We conclude that METTL has a significant anti hyperglycemic effect. Continuous glucose monitoring is needed in diabetic patients.


Keyword:     Streptozotocin (STZ) Glipizide Talinum Triangulare Synergistic effect Diabetes


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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