Research Article | Volume : 2 Issue : 5, May 2012

Liquisolid Compacts: An Approach to Enhance the Dissolution Rate of Nimesulide

Srinivas Vaskula Sateesh Kumar Vemula Vijaya Kumar Bontha Prasad Garrepally   

Open Access    DOI: 10.7324/JAPS.2012.2520

Abstract

The present study enlightens to enhance the dissolution rate, absorption efficiency and bioavailability of Nimesulide, a poorly soluble-highly permeable drug by preparing liquisolid compacts. Nimesulide liquisolid tablets were prepared by using polyethylene glycol-400 as a non-volatile liquid vehicle, microcrystalline cellulose, hydroxypropyl methylcellulose-E15, starch were used as carrier materials and silica gel as coating material in different ratios. They were characterized for different physical parameters to comply with pharmacopoeial limits. In vitro dissolution profiles of the liquisolid formulations were studied and compared with conventional formulation in pH 7.4 phosphate buffer and it was found that liquisolid tablets formulated with microcrystalline cellulose showed significant higher drug release rates than conventional tablets due to increase in wetting properties. DSC study showed that there is no interaction between the drug and excipients. In conclusion, development of nimesulide liquisolid tablets is a good approach to enhance the dissolution rate.


Keyword:     Carrier Dissolution rate Liquisolid compacts Liquid load factor Permeable.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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