Review Article | Volume : 1 Issue : 7, September 2011

Enhancement of Oral Bioavailability and Solid Dispersion: A Review

Nadia Saffoon Riaz Uddin Naz Hasan Huda Kumar Bishwajit Sutradhar   

Open Access   


Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. Most of the newly invented chemical entities are poorly water soluble. As a result formulating them as oral solid dosage forms is a hurdle to the specialists. Many techniques have been exercised to improve oral bioavailability of drugs. Among several methods, solid dispersion has attracted attention of the researchers for previous 50 years. Different formulation strategies have been taken to prepare solid dispersions. It is evident that solid dispersions improve solubility of drug particles thus enhancing dissolution characteristics of drugs they increase the oral bioavailability. This review paper will focus on different aspects of solid dispersion preparation; their advantages, major challenges and preparation methods.

Keyword:     Bioavailability Solubility Hot melt extrusion Carrier Biopharmaceutical classification Hot-spin-melting.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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