Research Article | Volume : 2 Issue : 5, May 2012

Assessment of the cytotoxic effect and in vitro evaluation of the anti-enteroviral activities of plants rich in flavonoids

Nabil Ben Salem Abid Zyed Rouis Mohamed Ali Lassoued Souad Sfar Mahjoub Aouni   

Open Access    DOI: 10.7324/JAPS.2012.2532

Abstract

Nanoparticles derived from plants known for their high content of flavonoids provide a biologically inspired route to designing therapeutic agents and a means of reducing nanoparticle toxicity. Little is currently known on the antiviral activity of Salvia officinalis L. and Washingtonia filifera H.Wendl aqueous extracts and their corresponding nanoparticles. In the present study, antiviral activity of subset extracts obtained from aerial parts of Salvia officinalis L. and Washingtonia filifera H.Wendl and nanoparticles derived from these plants were investigated against coxsackievirus B3 (CVB3). Different concentrations of extracts (7.8, 15.6, 31.25, 62.5, 125, 250, 500, and 1000 µg/mL) were tested for their cytotoxic effect and the antiviral activity was carried out using three non cytotoxic concentrations against CVB3 in Vero cells. The cell viability was carried out using tetrazolium dye (MTT). The experiment was carried out by incubating the extracts with either virus or cells prior to infection. The silver nanoparticles derived from the tested plant extracts enhance antiviral activity at non cytotoxic concentrations. The biosynthesized nanoparticles may be further characterized to better evaluate their antiviral potential against other viral pathogens.


Keyword:     Antiviral activity Enterovirus Nanoparticles Salvia officinalis Washingtonia filifera.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
387 Views 15 Downloads 402 Total

Year

Month

Related Search

By author names