Cancer continues to be a deadly disease on a global scale. Furthermore, despite the high expense of their development, synthetic chemotherapeutic drugs currently being used in clinical settings have failed to meet expectations during the past ten years. Therefore, new herbal medications might be alternative anticancer agents that are effective and affordable. Antioxidants in herbs might lessen oxidative stress and prevent carcinogenesis by slowing down and blocking the initiation of cancer cell development. Some researchers have reported that Pandanus tectorius has antioxidant activity. However, the antioxidant and anticancer properties of P. tectorius leave (PTL) in the form of self-nanoemulsifying drug delivery system (SNEDDS), specifically against human cervical cancer cells (HeLa) have not been studied. This study examined the anticancer activity of PTL-SNEDDS via induction of apoptosis on HeLa cells. All three PTL extracts (hexane, ethyl acetate, and methanol) were successfully formulated into SNEDDS formulation and showed improvement in antioxidant and anticancer activity compared to the crude extract. The cells’ morphological characteristics showed that PTL-SNEDDS-treated cells died from both early and late apoptosis. Thus, these findings introduce PTL-SNEDDS as an anticancer agent against human cervical cancer.
Kholieqoh AH, Kassim MNI, Muhammad TST, Anam K, Sung YY, Amir H, Praja HN, Andriani Y. SNEDDS to improve the bioactivities of Pandanus tectorius leaves: Optimization, antioxidant, and anticancer activities via apoptosis induction in human cervical cancer cell line. J Appl Pharm Sci. 2024. Online First. http://doi.org/10.7324/JAPS.2024.168694
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