Research Article | Volume: 8, Issue: 9, September, 2018

Stability Study of Ipomoea reptans Extract Self-Nanoemulsifying Drug Delivery System (SNEDDS) as Anti-Diabetic Therapy

Pinus Jumaryatno Lutfi Chabib Farida Hayati Rizki Awaluddin   

Open Access   

Published:  Sep 30, 2018

DOI: 10.7324/JAPS.2018.8903

Diabetes mellitus (DM) is one of the metabolic syndromes that is characterized by the excessive accumulation of blood glucose, also called as hyperglycemia, and carbohydrate, fat, and protein metabolism disorder. The antioxidant compounds on Ipomoea reptans possess the pharmacological activity of DM with low absorption in the systemic circulation. Stability is one of the factors that affect the safety, quality, and efficacy of the SNEDDS (Self- Nanoemulsifying Drug Delivery) dosage form. This study aimed to evaluate the stability of Ipomoea reptans leaf extract (IPE) SNEDDS. The IPE SNEDDS was made using capryol 90 as the oil phase, tween 20 as surfactants, and polyethylene glycol (PEG) 400 as the cosurfactant. The stability study was conducted with several physical stability tests, which were centrifugation test, heating-cooling cycle test, and freeze-thaw cycle test. The result indicated that the particle size of the IPE SNEDDS was ≤100 nm and indicated good physical stability. It can be concluded that the IPE SNEDDS possesses good stability profile.

Keyword:     Ipomoea reptans SNEDDSStability Capryol 90Diabetes Mellitus.


Jumaryatno P, Chabib L, Hayati F, Awaluddin R. Stability Study of Ipomoea reptans Extract Self-Nanoemulsifying Drug Delivery System (SNEDDS) as Anti-Diabetic Therapy. J App Pharm Sci, 2018; 8(09): 011-014.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Anton N, Thierry V. Nano-emulsions and Micro-emulsions: Clarifications of the Critical Differences. Pharm. Res. 2011; 28:978–985.

Chabib L, Muhtadi WK, Ikawati Z, Martien R, Ismail H. Stability Study of Gamavuton (Gvt-0) Self-Nanoemulsifying Drug Delivery System (Snedds) with Myritol as The Oil Phase. Int. J. Curr. Inov. Res. 2017; 3:590–594.

Dolati S, Sadreddini S, Rostamzadeh D, Ahmadi M, ScienceDirect Utilization of nanoparticle technology in rheumatoid arthritis treatment. Biomed. Pharmacother. 2016; 80:30–41.

Gupta S, Chavhan S, Sawant KK. Self-Nanoemulsifying Drug Delivery System for Adefovir Dipivoxil: Design, Characterization, In Vitro and Ex Vivo Evaluation. Colloids Surf A Physicochem Eng Asp. 2011; 392:145–155.

Fanun M, Microemulsions as Delivery Systems. Curr. Opin. Colloid Interface Sci. 2012; 17:166–172.

Hayati F, Lulung W, Marsih L. The Effect Of Ipomoea reptans Poir Ethanolic Extract On The Histopathological Parameters Of Pancreas In Streptozotocin-Induced Diabetic Rats. Int. Conf. Chem. Chem. Process Eng. 2017; 20046.

Hayati F, Wibowo A, Jumaryatno P, Nugraha AT. Standardization of the Extract of Cultivated Ipomoea reptans Poir. Leaves from Sardonoharjo, Sleman and Its Potency as Antioxidant). J. Ilmu Kefarmasian Indones. 2015; 13.

Hayati F, Windyarini S, Helminawati. Efek Antihiperglikemik Infusa Kangkung Darat (Ipomoea reptans Poir) pada mencit jantan galur Swiss yang diinduksi Streptozotocin. J. Ilm. Farm. 2010; 7:13–22.

Jain N, Jain R, Thakur N, Gupta BP, Jain DK, Jain S. Nanotechnology: A Safe And Effective Drug Delivery System. Asian J. Pharm. Clin. Res. 2010; 3:159–165.

Lyons TJ, Jenkins AJ. Glycation, oxidation, and lipoxidation in the development of the complications of diabetes: a carbonyl stress hypothesis. Diabetes Rev (Alex), 1997; 5:365–391.

Makadia MHA, Bhatt MAY, Parmar RB, Paun MJS, Tank HM. Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects. Asian J. Pharm. Res. 2013; 3:21–27.

Mamun-or-Rashid ANM, Hossain S, Hassan N, Dash K, Sapon A, Sen MK. A review on medicinal plants with antidiabetic activity. 2014; 3:149–159.

Manvar M, Desai T. Phytochemical and Pharmacological Profile of Ipomoea Aquatica. Indian J. Med. Sci. 2013; 67:49–60.

Mao L, Xu D, Yang J, Yuan F, Gao Y, Zhao J. Effects of Small and Large Molecule Emulsifiers on the Characteristics of b-Carotene Nanoemulsions Prepared by High Pressure Homogenization. Food Technol. Biotechnol. 2009; 9862:336–342.

Patel P, GM C, A A. Self Emulsifying Drug Delivery System. Res. J. Pharm. Technol. 2008; 1.

Rao SVR, Shao J. Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: I. Formulation development. Int. J. Pharm. 2008; 362:2–9.

Sabu MC, Kuttan R. Antidiabetic activity of selected medicinal plants and its possible mechanism of action Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J. Ethnopharmacol. 2014.

Shah P, Bhalodia D, Shelat P. Nanoemulsion: A pharmaceutical review. Syst. Rev. Pharm. 2010; 1:24.

Shukla JB, Patel SJ. Formulation And Evaluation Of Self Micro Emulsifying System Of Candesartan Cilexetil. Int. J. Pharm. Pharm. Sci. 2010; 2:2–5.

Sucharitha E, Estari M. Evaluation of antidiabetic activity of medicinal plant extracts used by tribal communities in rural areas of Warangal district, Andhra Pradesh, India. Biology and Medicine. Biol. Med. 2013; 5:20–25.

Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options. Curr Neuropharmacol. 2009; 7:65-74.

Yen C, Chang C, Hsu M-C, Wu Y-T. Self-Nanoemulsifying Drug Delivery System for Resveratrol: Enhanced Oral Bioavailability and Reduced Physical Fatigue in Rats. Int. J. Mol. Sci. 2017; 18.

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