Neuroprotective effects of g-Aminobutyric acid-enriched germinated riceberry extract in cerebral ischemic reperfusion-induced cognitive impairment mice

PayungsakTantipaiboonwong KomsakPintha NapapanKangwan DejMann PrathakphongRiyamongkhol Watcharaporn Preedapirom Jeefoo   

Open Access   

Published:  Jun 12, 2024

DOI: 10.7324/JAPS.2024.175285

This study investigates the neuroprotective effects of riceberry (RB) and germinated riceberry (GRB) extracts on cognitive impairment induced by cerebral ischemia-reperfusion (IR) injury. Our findings indicate that the germination process reduces total phenolic content and total antioxidant capacity, accompanied by a decline in antioxidant activity. However, the enriched γ-aminobutyric acid (GABA) content significantly increased in the GRB extract, reaching an 11.55-fold higher concentration than the RB extract. Male ICR mice were used in this study and received RB (500 mg/kg BW) or GRB (250 and 500 mg/kg BW) extracts for 28 days, with cerebral IR injury induced on day 21. Memory and learning were assessed using the Morris water maze on days 22–27 and novel object recognition on day 28. Both RB and GRB extracts improved spatial and recognition memory while reducing hippocampal malondialdehyde levels, indicating decreased oxidative stress. GRB demonstrated superior effects, displaying accelerated learning responses and enhanced retention of spatial memory. The study highlights the potential of GRB, attributed to its high GABA content, in mitigating cognitive impairment induced by cerebral IR injury. Further research is needed to explore the underlying mechanisms and optimize therapeutic applications.

Keyword:     Germinated riceberry extract Ý-aminobutyric acid cerebral ischemic-reperfusion neuroprotective effects cognitive impairment


Tantipaiboonwong P, Pintha K, Kangwan N, Mann D, Riyamongkhol P, Jeefoo WP. Neuroprotective effects of γ-Aminobutyric acid-enriched germinated riceberry extract in cerebral ischemic reperfusion-induced cognitive impairment mice. J Appl Pharm Sci. 2024. Online First.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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