Functionalized carbon nanotubes—A boon in treating brain diseases
Rajkumar Ghosh1, Jagabandhu Bag2, Aparna Datta2, Arup Pramanick2, Isa Hassan Abubakar3
1Department of Pharmacy, Birbhum Pharmacy College, Birbhum, India.
2Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata, India.
3School of Allied Health and Sciences, Sharda University, Noida, India.
Open Access
Published: Feb 25, 2023
DOI: 10.7324/JAPS.2023.107158Typical intrinsic properties of carbon nanotube (CNTs) like one-dimensional structure with very high mechanical strength, high thermal and electrical conductivity, high aspect ratio, high surface area, ability to conjugate with functional groups, and elevated surface functionalizing capacity have made it a nanostructure of choice to be manipulated for drug delivery for the past two decades. The human brain restricts movements and or entry of ions, molecules, and cells between the blood and the brain because of the presence of the blood–brain barrier. As a result, administering drug molecules of choice to the brain under disease condition become constrained. Surface functionalized CNTs can render themselves efficient as drug carriers to the neurons, for extreme conditions like Alzheimer’s disease, glioblastoma, Parkinson’s disorder, brain stroke, brain tumor, etc. This review discussed in detail the advancement achieved so far in delivering drug molecules to the brain using CNT as the carrier and related management of toxicity so that a safer dose delivery can be made.
Ghosh R, Bag J, Datta A, Pramanick A, Abubakar IH. Functionalized carbon nanotubes—A boon in treating brain diseases. J Appl Pharm Sci, 2023. https://doi.org/10.7324/JAPS.2023.107158
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