Research Article | Volume : 2 Issue : 3, March 2012

Comparative Study on HDL-Cholesterol Raising Effects of Atorvastatin and Dehydrolovastatin

Marissa Angelina Indah D. Dewijanti Tri YulianiYulia Anita Lia Meilawati Mas Jaya Putra Andrianopsyah Hanafi Muhammad   

Open Access    DOI: 10.7324/JAPS.2012.2303

Abstract

HDL-cholesterol raising effect of atorvastatin was compared to that of dehydrolovastatin in an 8-week study in 5 equally-membered groups of pre-acclimatized Sprague-Dawley rats. The first and second groups were normal and hyperlipidemic control, while the others were treated with atorvastatin 14.4 mg, dehydrolovastatin 7.2 mg, and dehydrolovastatin 14.4 mg, per 200 g of mouse body weight per day, respectively. Slightly better effect than atorvastatin €™s could only be achieved by dehydrolovastatin with the same dose.


Keyword:     cholesterolHDLatorvastatindehydrolovastatin


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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