Research Article | Volume : 2 Issue : 3, March 2012

Comparative Study on HDL-Cholesterol Raising Effects of Atorvastatin and Dehydrolovastatin

Marissa Angelina,  Indah D. Dewijanti,  Tri Yuliani, Yulia Anita,  Lia Meilawati,  Mas Jaya Putra,  Andrianopsyah,  Hanafi Muhammad   
Marissa Angelina, Indah D. Dewijanti, Tri Yuliani,Yulia Anita, Lia Meilawati, Mas Jaya Putra, Andrianopsyah, Hanafi Muhammad

LIPI Research Center for Chemistry (Pusat Penelitian Kimia – LIPI), Kawasan Puspiptek, Tangerang Selatan, Banten, Indonesia 15314.

Open Access    DOI: 10.7324/JAPS.2012.2303

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Abstract

HDL-cholesterol raising effect of atorvastatin was compared to that of dehydrolovastatin in an 8-week study in 5 equally-membered groups of pre-acclimatized Sprague-Dawley rats. The first and second groups were normal and hyperlipidemic control, while the others were treated with atorvastatin 14.4 mg, dehydrolovastatin 7.2 mg, and dehydrolovastatin 14.4 mg, per 200 g of mouse body weight per day, respectively. Slightly better effect than atorvastatin €™s could only be achieved by dehydrolovastatin with the same dose.


Keyword:     cholesterolHDLatorvastatindehydrolovastatin

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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