Research Article | Volume : 2 Issue : 2, February 2012

Antihyperlipidaemic Activity of Spermacoce Hispida Ethanolic Extract in Triton WR-1339 Induced Hyperlipidaemic Rats

G. Sivaelango,  P. Senthil Kumaran,  P. Kumaravel,  P. Revathi,  A. Jaswant   
G. Sivaelango1, P. Senthil Kumaran2, P. Kumaravel3, P. Revathi4, A. Jaswant5

1Department of Biochemistry, Vysya College, Salem-636 103, Tamil Nadu, India.

2Department of Biochemistry, Bharathidasan College of Arts and Science, Erode- 638 116, Tamil Nadu, India.

3Department of Biotechnology, Vysya College, Salem-636 103, Tamil Nadu, India.

4Department of Chemistry, Government Arts college (Autonomous), Salem636 007.

5Department of Pharmacology, Periyar college of Pharmaceutical sciences for Girls, Tiruchirappalli- 620 021.

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Abstract

Hyperlipidaemia is the greatest risk factor of coronary heart disease. Currently available hypolipidaemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidaemia has no side effects and is relatively cheap and locally available. Literature claims that Saponins are able to reduce hyperlipidemia. Based on high saponin content in herbal plants, Spermacoce hispida (S. hispida) was selected and the present study focus on the antihyperlipidaemic activity of ethanolic seed extract of S. hispida against triton-WR-1339 induced hyperlipidaemia in rats. Hyperlipidaemia was induced in Wistar rats by intraperitoneal (i.p) injections of Triton WR-1339 at a dose of 400 mg/kg body weight. S. hispida was administered orally at a dose of 200 mg/kg to triton WR-1339 induced hyperlipidaemic rats. After administration of S. hispida shows a significant decrease in the levels of cholesterol, phospholipids, triglycerides, LDL, VLDL and significant increase in the level of HDL in serum and liver tissues against triton induced hyperlipidaemic in rats. Therefore it effectively suppressed the triton induced hyperlipidemia in rats, suggesting the potential protective role in Coronary heart disease.


Keyword:     Hyperlipidaemia Triton WR-1339 S. hispida Cholesterol.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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