Wound healing effect of snakehead fish (Channa striata) mucus containing transdermal patch

Besse Yuliana; Sartini; Natsir Djide; Yulia Yusriani Djabir

Abstract

Snakehead fish (Channa striata) has a high albumin content which contributes to the formation of new tissues in wound healing. The purpose of this study was to develop and evaluate the patch for transdermal delivery containing albumin from snakehead fish mucus in wound healing of diabetic Wistar rats (Rattus norvegicus). The albumin content in the snakehead fish mucus was analyzed by UV-Vis spectrophotometry. The patch was formulated by three different snakehead fish mucus extracts (1%, 3%, and 5%), and their physicochemical properties were determined. Wound healing was evaluated toward normal and diabetic rats. All data were analyzed by statistical analysis. The results showed that albumin content in the mucus extract was 27.73 µg/l. Organoleptic properties evaluation showed a brown color patch with a smooth surface and homogeneous weight. The pH and moisture were within the requirement of the patch. The activity of the positive control group, formula F(+), showed no significant difference from the action of formula F3 on the eighth day of treatment. These data indicate that the formulation of patch transdermal containing snakehead fish mucus extract is prominent to be developed for the wound healing treatment of diabetic ulcers.

Keyword: Patch albumin diabetic ulcers snakehead fish wound healing mucus.

Citation:

Yuliana B, Sartini S, Djide N, Djabir YY. Wound healing effect of snakehead fish (Channa striata) mucus containing transdermal patch. J Appl Pharm Sci, 2022; 12(07):173–185.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reference

Adu MD, Malabu UH, Malau-Aduli AEO, Malau-Aduli BS. Enablers and barriers to effective diabetes self-management: a multinational investigation. PLoS One, 2019; 14(6):e0217771. https://doi.org/10.1371/journal.pone.0217771

Alexiadou K, Doupis J. Management of diabetic foot ulcers. Diabetes Ther, 2012; 3(1):4. https://doi.org/10.1007/s13300-012-0004-9

Ansar W, Ghosh S. Inflammation and inflammatory diseases, markers, and mediators: role of CRP in some inflammatory diseases. In: Ansar W, Ghosh S (eds.). Biology of C reactive protein in health and disease, Springer India, New Delhi, India, pp 67-107. https://doi.org/10.1007/978-81-322-2680-2_4

Arun M, Satish S, Anima P. Evaluation of wound healing, antioxidant, and antimicrobial efficacy of Jasminum auriculatum Vahl. Leaves. Avicenna J Phytomed, 2016; 6(3):295-304.

American Diabetes Association (ADA). Diagnosis and classification of diabetes mellitus. Diabetes Care, 2009; 32(Suppl 1):S62-7. https://doi.org/10.2337/dc09-S062

Basi S, Lewis JB. Microalbuminuria as a target to improve cardiovascular and renal outcomes. Am J Kidney Dis, 2006; 47:927-46. https://doi.org/10.1053/j.ajkd.2006.02.182

Baie SH, Sheikh KA. The wound healing properties of Channa striatus-cetrimide cream-- tensile strength measurement. J Ethnopharmacol, 2000; 71(1-2):93-100. https://doi.org/10.1016/S0378-8741(99)00184-1

Cherukuri S, Batchu UR, Mandava K, Cherukuri V, Ganapuram KR. Formulation and evaluation of transdermal drug delivery of topiramate. Int J Pharm Investig, 2017; 7(1):10-7. https://doi.org/10.4103/jphi.JPHI_35_16

Dang L, Seale JP, Qu X. High glucose-induced human umbilical vein endothelial cell hyperpermeability is dependent on protein kinase C activation and independent of the Ca2 + -nitric oxide signalling pathway. Clin Exp Pharmacol Physiol, 2005; 32:771-6. https://doi.org/10.1111/j.1440-1681.2005.04266.x

Dumville JC, O'Meara S, Deshpande S, Speak K. Alginate dressings for healing diabetic foot ulcers. Cochrane Database Syst Rev, 2013; 2013(6):Cd009110. https://doi.org/10.1002/14651858.CD009110.pub3

Everett E, Mathioudakis N. Update on management of diabetic foot ulcers. Ann N Y Acad Sci, 2018; 1411(1):153-65. https://doi.org/10.1111/nyas.13569

Fawwaz M, Vemilia P, Mutmainnah I, Baits M. Scylla serrata forskal as natural source of glucosamine hydrochloride. Marmara Pharm J, 2019; 23(2):259-66. https://doi.org/10.12991/jrp.2019.132

Fawwaz M, Baits M, Saleh A, Irsyaq MR, Pratiwi RE. Isolation of Glucosamine HCl from Penaeus monodon. Int Food Res J, 2018; 25(5):2173-6.

Fawwaz M, Mishiro K, Nishii R, Sawazaki I, Shiba K, Kinuya S, Ogawa K. Synthesis and fundamental evaluation of radioiodinated rociletinib (CO-1686) as a probe to lung cancer with L858R/T790M Mutations of Epidermal Growth Factor Receptor (EGFR). Molecules, 2020; 25(12):2914. https://doi.org/10.3390/molecules25122914

Fuadi M, Santoso H, Syauqi A. Albumin level test of snakehead fish (Channa striata) in different salinity environment. Bioscience-Tropic, 2017; 3(1):23-30.

Guo S, DiPietro LA, Factors affecting wound healing. J Dent Res, 2010; 89(3):219-29. https://doi.org/10.1177/0022034509359125

Haniffa MAK, Jeya Sheela PA, Kavitha K, Jais AMM. Salutary value of haruan, the striped snakehead Channa striatus a review. Asian Pac J Trop Biomed, 2014; 4:S8-15. https://doi.org/10.12980/APJTB.4.2014C1015

Ighodaro OM, Adeosun AM, Akinloye OA. Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina, 2017; 53(6):365-74. https://doi.org/10.1016/j.medici.2018.02.001

Jais AMM, McCulloch R, Croft K. Fatty acid and amino acid composition in haruan as a potential role in wound healing. Gen Pharmacol Vasc Syst, 1994; 25(5):947-50. https://doi.org/10.1016/0306-3623(94)90101-5

Jahandideh M, Hajimehdipoor H, Mortazavi SA, Dehpour A, Hassanzadeh G. Evaluation of the wound healing activity of a traditional compound herbal product using rat excision wound model. Iran J Pharm Sci, 2017; 16(special issue):153-63.

Kannur DM, Hukkeri VI, Akki KS. Antidiabetic activity of Caesalpinia bonducella seed extracts in rats. Fitoterapia, 2006; 77(7-8):546-9. https://doi.org/10.1016/j.fitote.2006.06.013

Keleb E, Sharma R, Mosa EB, Zaljahwi AZ. Transdermal drug delivery system- design and evaluation. Int J Adv Pharm Sci, 2010; 1:201-11.

Kokane DD, More RY, Kale MB, Nehete MN, Mehendale PC, Gadgoli CH. Evaluation of wound healing activity of root of Mimosa pudica. J Ethnopharmacol, 2009; 124(2):311-5. https://doi.org/10.1016/j.jep.2009.04.038

Malone-Povolny MJ, Maloney SE, Schoenfisch MH. Nitric oxide therapy for diabetic wound healing. Adv Healthc Mater, 2019; 8(12):e1801210. https://doi.org/10.1002/adhm.201801210

Molnar JA, Underdown MJ, Clark WA. Nutritionand chronic wounds. Adv Wound Care, 2014; 3(11):663-81. https://doi.org/10.1089/wound.2014.0530

Nurmesa A, Nurhabibah, Najihudin A. Formulasi dan Evaluasi Stabilitas Fisik Patch Transdermal Alkaloid Nikotin Daun Tembakau (Nicotiana tobacum Lin) dengan Variasi Polimer dan Asam Oleat. Jurnal Penelitian Farmasi Herbal, 2019; 2(1): 1-8. https://doi.org/10.36656/jpfh.v2i1.124

Palta S, Saroa R, Palta A. Overview of the coagulation system. Indian J Anaesth, 2014; 58(5):515-23. https://doi.org/10.4103/0019-5049.144643

Plante GE, Chakir M, Lehoux S, Lortie M: Disorders of body fluid balance: a new look into the mechanisms of disease. Can J Cardiol, 1995; 11:788-802.

Rahayu P, Marcelline F, Sulistyaningrum E, Suhartono MT, Tjandrawinata RR. Potential effect of striatin (DLBS0333), a bioactive protein fraction isolated from Channa striata for wound treatment. Asian Pac J Trop Biomed, 2016; 6(12):1001-7. https://doi.org/10.1016/j.apjtb.2016.10.008

Ramadhanti NA, Sandhika W, Widodo ADW. The effect of snakehead fish (Channa striata) extract on inflammation reaction of skin wound tissue in Rattus novergicus Wistar strain. Periodical Dermatol Venereol, 2021; 33(1):48-54. https://doi.org/10.20473/bikk.V33.1.2021.48-54

Ramirez-Acuña JM, Cardenas-Cadena SA, Marquez-Salas PA, Garza-Veloz I, Perez-Favila A, Cid-Baez MA, Flores-Morales V, MartinezFierro ML. Diabetic foot ulcers: current advances in antimicrobial therapies and emerging treatments. Antibiotics (Basel), 2019; 8(4). https://doi.org/10.3390/antibiotics8040193

Saco M, Howe N, Nathoo R, Cherpelis B. Comparing the efficacies of alginate, foam, hydrocolloid, hydrofiber, and hydrogel dressings in the management of diabetic foot ulcers and venous leg ulcers: a systematic review and meta-analysis examining how to dress for success. Dermatol Online J, 2016; 22(8). https://doi.org/10.5070/D3228032089

Sahid NA, Hayati F, Rao CV, Ramely R, Sani I, Dzulkarnaen A, Zakaria Z, Hassan S, Zahari A, Ali AA. Snakehead consumption enhances wound healing? From tradition to modern clinical practice: a prospective randomized controlled trial. Evid Based Complement Alternat Med. 2018; 2018:3032790. https://doi.org/10.1155/2018/3032790

Shu DY, Hutcheon AEK, Zieske JD, Guo X. Epidermal growth factor stimulates transforming growth factor-beta receptor type II expression in corneal epithelial cells. Sci Rep, 2019; 9(1):8079. https://doi.org/10.1038/s41598-019-42969-2

Sikarwar MS, Patil MB. Antidiabetic activity of Crateva nurvala stem bark extracts in alloxan-induced diabetic rats. J Pharm Bioallied Sci, 2010; 2(1):18-21. https://doi.org/10.4103/0975-7406.62700

Smith SA, Travers RJ, Morrissey JH. How it all starts: Initiation of the clotting cascade. Crit Rev Biochem Mol Biol, 2015; 50(4):326-36. https://doi.org/10.3109/10409238.2015.1050550

Song I, Patel O, Himpe E, Muller CJF, Bouwens L. Beta cell mass restoration in alloxan-diabetic mice treated with EGF and gastrin. PLoS One, 2015; 10(10):e0140148. https://doi.org/10.1371/journal.pone.0140148

Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res, 2001; 50(6):537-46.

Tungadi R, Attamimi F, Sabu EF, Nugraha E. The acceleration of wound healing of snakehead fish cream towards rabbit's skin wound histopathologically. Indonesian J Pharm Sci, 2011; 9(2):91-7.

Ozgok Kangal MK, Regan JP. Wound Healing [Online], 2021. Available via https://pubmed.ncbi.nlm.nih.gov/30571027/

Utariani A, Rahardjo E, Perdanakusuma DS. Effects of albumin infusion on serum levels of albumin, proinflammatory cytokines (TNF-α, IL-1, and IL-6), CRP, and MMP-8; Tissue expression of EGRF, ERK1, ERK2, TGF-β, collagen, and MMP-8; and wound healing in sprague dawley rats. Int J Inflam, 2020; 2020:3254017. https://doi.org/10.1155/2020/3254017

Volmer-Thole M, Lobmann R. Neuropathy and diabetic foot syndrome. Int J Mol Sci, 2016; 17(6). https://doi.org/10.3390/ijms17060917

WHO. Diabetes [Online], 2021. Available via https://www.who. int/news-room/fact-sheets/detail/diabetes

Yazdanpanah L, Shahbazian H, Nazari I, Arti HR, Ahmadi F, Mohammadianinejad SE, Cheraghian B, Hesam S. Incidence and risk factors of diabetic foot ulcer: a population-based Diabetic Foot Cohort (ADFC Study)-two-year follow-up study. Int J Endocrinol, 2018; 2018:7631659. https://doi.org/10.1155/2018/7631659

Zuraini A, Somchit MN, Solihah MH. Fatty acid and amino acid composition of three local Malaysian Channa spp. fish. Food Chem, 2006; 97(4):674-8. https://doi.org/10.1016/j.foodchem.2005.04.031

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