Toddalia asiatica (L) Lam is a liana commonly known as an orange climber and is a monotypic genus belonging to the family “Rutaceae.” It is one of the widely distributed medicinal plants in the countries, i.e., South Africa, north tropical regions of Africa, Asia, and also in Madagascar. Compounds that exhibit various pharmacological effects, isolated from the various parts of the plant Toddalia asiatica, such as root, root bark, stem, stem bark, flowers, fruits, and leaves have been of prime importance. Traditional medicinal practitioners of the Asian continent have been using this plant since ancient times to treat ailments such as pulmonary diseases and inflammation of joints known as rheumatism. The root and the root bark of the plant are said to be more potent and are used as a remedy for the conditions such as fever, malaria, cholera, diarrhea, neuralgia, sprains, and epilepsy. Fruits of the plant are used as a medication in the conditions, i.e., cough, digestive abnormalities, and viral influenza infection. The vital oil obtained from the root bark of the plant T. asiatica is known to produce strong larvicidal activity against the mosquito species Aedes. The present review emphasizes a variety of pharmacologically active secondary metabolites extracted from the medicinal plant T. asiatica such as coumarins, toddaculin, toddalactone, and their pharmacological effects such as in antiinflammatory, bactericidal, fungicidal, antimalarial, antidiabetic, antiviral, and antitumor activity
Lakshmi SJ, Siddiraju UR. Comprehensive study of secondary metabolite profile and pharmacological effects of medicinal plant Toddalia asiatica. J Appl Pharm Sci, 2022; 12(07):042–052.
Akbari B, Baghaei-Yazdi N, Bahmaie M, Mahdavi Abhari F. The role of plant-derived natural antioxidants in reduction of oxidative stress. BioFactors, 2022. https://doi.org/10.1002/biof.1831
Alagaraj P, Muthukrishnan S. Toddalia asiatica L.-a rich source of phytoconstituents with potential pharmacological actions, an appropriate plant for recent global arena. Cardiovasc Hematol Agents Med Chem. 2020; 18(2):104-10. https://doi.org/10.2174/1871525718666200212095756
Amuka O, Machocho AK, Okemo PO, Mbugua PK. Antibacterial and antifungal activities of essential oils from Satureiabiflora D. Don, Benth, Speng (Chepsagitiet). Lippiajavanica Burm.F. (Labotuet) and Toddalia asiatica (L) Lam. Rutaceae (Chepindoruet). Glob J Sci Front Res B Chem, 2014; 14:133.
Arul M, Veerappa NS. Pharmacognostical analysis of Fruit of Toddalia asiatica (L.) Lam. (Rutaceae). Res J Pharmacogn Phytochem, 2019; 11(3):193-6. https://doi.org/10.5958/0975-4385.2019.00033.5
Balasubramaniam A, Manivannan R, Paramaguru R, Mazumder PM, Vijayakumar M. Evaluation of anti-inflammatory and antioxidant activities of stem bark of Toddalia asiatica (L) lam. using different experimental models. Pharmacologia, 2012; 3(5):144-9. https://doi.org/10.5567/pharmacologia.2012.144.149
Chen SS, Xie TZ, He YJ, Liu YY, Li L, Zhao LX, Luo XD. Alkaloids of Toddalia asiatica (Rutaceae). Biochem Syst Ecol, 2021; 95:104244. https://doi.org/10.1016/j.bse.2021.104244
Ding W, Wen CF, Chen JH, Huang KX, Dong AW. Primary study on antibacterial activity of extracts from Toddalia asiatica (Linn.) lam. Biomass. Chem Eng, 2007; 41(5):33-5.
Doumouchtsis KK, Doumouchtsis SK, Doumouchtsis EK, Perrea DN. The effect of lead intoxication on endocrine functions. J Endocrinol Invest, 2009; 32:175-83. https://doi.org/10.1007/BF03345710
Duraipandiyan V, Ignacimuthu S. Antibacterial and antifungal activity of Flindersine isolated from the traditional medicinal plant, Toddalia asiatica (L.) Lam. J Ethnopharmacol, 2009; 123(3):494-8. https://doi.org/10.1016/j.jep.2009.02.020
Fialova S, Rendekova K, Mucaji P, Slobodnikova, L. Plant natural agents: polyphenols, alkaloids and essential oils as perspective solution of microbial resistance. Curr Organ Chem, 2017; 21(18):1875-84. https://doi.org/10.2174/1385272821666170127161321
Guo JY, Sun Y, Wang YK, Liu X. Study on isolation of endophytic fungi from Toddalia asiatica and their antimicrobial activity. J Guangdong Pharm Univ, 2014; 30:422-6.
He N, Wang P, Wang P, Ma C, Kang W. Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam. BMC Complement Altern Med, 2018; 18(1):1-9. https://doi.org/10.1186/s12906-018-2317-3
He YK, Da RX, Hua XA, Xiu YY. Effects of aqueous extract from Toddalia asiatica on cardiac function and hemodynamics in myocardial ischemic rabbits. Chinese J Pathophysiol, 2000; 16(606-609).
Hirunwong C, Sukieum S, Phatchana R, Yenjai C. Cytotoxic and antimalarial constituents from the roots of Toddalia asiatica. Phytochem Lett, 2016; 17:242-6. https://doi.org/10.1016/j.phytol.2016.08.008
Hu J, Shi X, Chen J, Mao X, Zhu L, Yu L, Shi J. Alkaloids from Toddalia asiatica and their cytotoxic, antimicrobial, and antifungal activities. Food Chem, 2014; 148:437-44. https://doi.org/10.1016/j.foodchem.2012.12.058
Hu XY, Zeng FB, Cui XR, Li YR. Studies on analgesic and antiinflammatory effects and toxicity of ethanol extract from Toddalia asiatica. Chinese J Trad Med Sci Technol, 2000; 7:231-2.
Irudayaraj SS, Jincy J, Sunil C, Duraipandiyan V, Ignacimuthu S, Chandramohan G, Packiam SM. Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats. J Ethnopharmacol, 2022; 285(1):114883. https://doi.org/10.1016/j.jep.2021.114883
Jain SC, Pandey MK, Upadhyay RK, Kumar R, Hundal G, Hundal MS. Alkaloids from Toddalia aculeata. Phytochemistry, 2006; 67(10):1005-10. https://doi.org/10.1016/j.phytochem.2006.03.012
Kariuki HN, Kanui TI, Yenesew A, Patel N, Mbugua PM. Antinociceptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice. Pan Afr Med J, 2013; 14:133. https://doi.org/10.11604/pamj.2013.14.133.2130
Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EGT, Swapna S, Bellamkonda R, Chippada Appa R. Antihyperglycemic and antihyper- lipidemic activities of methanol: water (4:1) fraction isolated from aqueous extract of Syzgiumalternifolium seeds in streptozotocin induced diabetic rats. Food Chem Toxicol, 2010; 48:1078-84. https://doi.org/10.1016/j.fct.2010.01.029
Khandelwal P, Upendra R. S, Raftani amiri Z, Ramachandra GG. Assessment of biotherapeutic potential of Pimenta dioica (Allspice) leaf extract. Int J Pharm Sci Res, 2012; 3(9):1000-4.
Khandelwal Pratima, Upendra RS, Yashaswini R, Subha B, Sneha G, Ramachandra GG. Comparative studies on biotherapeutic potentials of two selected medicinal plants-Pimenta dioica and Epiphyllum oxypetalum. World J Pharm Pharm Sci, 2013; 2(4):1789-801.
Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Abete P. Oxidative stress, aging, and diseases. Clin Interv Aging, 2018; 13:757. https://doi.org/10.2147/CIA.S158513
Liu M, Liu Y, Deng Y, Zulin HU. Effects of Toddalia asiatica extract on inflammatory cytokines in rats with myocardial ischemia and hyperlipidemia. Chinese J Comp Med, 2018; 28(2):64-8.
Luo C, Liu J, Liang Y, Shen X, Zhang X, Zhou W. Antitumor chemical constituents of Toddalia asiatica (Linn) Lam root bark and its rational alternative medicinal parts by multivariate statistical analysis. Acta Chromatogr, 2021; 33(2):153-61. https://doi.org/10.1556/1326.2020.00762
Ma W, Ali I, Li Y, Hussain H, Zhao H, Sun X, Wang D. A simple and efficient two-dimensional high-speed counter-current chromatography linear gradient and isocratic elution modes for the preparative separation of coumarins from roots of Toddalia asiatica (Linn.) Lam. Molecules, 2021; 26(19):5986. https://doi.org/10.3390/molecules26195986
Nabwami J, Tabuti J, Bekundai MA. Characterization of the natural habitat of Toddalia asiatica in the Lake Victoria basin: soil characteristics and seedling establishment. Afr Crop Sci Conf Proc, 2007; 8:2057-61.
Nattudurai G, Paulraj MG, Ignacimuthu S. Toddalia asiatica (L.) Lam. essential oil: a potential natural fumigant and repellent against three coleopteran pests of stored products. Int J Pure Appl Zool, 2014; 2(3):246-55.
Nelson L, Shih R, Hoffman R. Aplastic anaemia induced by an adulterated herbal medication. J Toxicol Clin Toxicol, 1995; 33(5):467-70. https://doi.org/10.3109/15563659509013756
Ngarivhume T, van't Klooster CI, de Jong JT, Van der Westhuizen JH. Medicinal plants used by traditional healers for the treatment of malaria in the Chipinge district in Zimbabwe. J Ethnopharmacol, 2015; 159:224-37. https://doi.org/10.1016/j.jep.2014.11.011
Ni J, Zhao Y, Su J, Liu Z, Fang S, Li L, Deng J, Fan G. Toddalolactone protects lipopolysaccharide-induced sepsis and attenuates lipopolysaccharide-induced inflammatory response by modulating HMGB1-NF-κB translocation. Front Pharmacol, 2020; 21(11):109. https://doi.org/10.3389/fphar.2020.00109
Njoroge GN, Bussmann RW. Diversity and utilization of antimalarial ethnophytotherapeutic remedies among the Kikuyus (Central Kenya). J Ethnobiol Ethnomed, 2006; 2:1-8. https://doi.org/10.1186/1746-4269-2-8
Önder, A. Anticancer activity of natural coumarins for biological targets. Stud Nat Prod Chem, 2020; 64:85-109. https://doi.org/10.1016/B978-0-12-817903-1.00003-6
Orwa JA, Jondiko IJ, Bii C. Antimicrobial activity of aqueous and organic solvent extracts from a Kenyan medicinal plant, Toddalia asiatica (L) Lam. J Afr Health Sci, 2015; 28(1):80-6.
Praveena C, Veeresham C. Benzophenanthridine alkaloids from callus cultures of Toddalia asiatica. Int J Pharm Sci Nano Technol, 2015; 8:3003-8. https://doi.org/10.37285/ijpsn.2015.8.4.2
Prithviraj SR, Nitesh Kumar T, Shahid Khan A, Upendra RS, Ahmed MR. The role of immunity and immune boosting food in combating covid-19 global pandemic. Int J Pharm Res, 2021; 13(2):2816. https://doi.org/10.31838/ijpr/2021.13.02.323
Punitha R, Manohara S. Antihyperglycemic and antilipidperoxidative effects of Pongamia pinnata (Linn.) Pierre flowers in alloxan induced diabetic rats. J Ethnopharmacol, 2006; 105:39-46. https://doi.org/10.1016/j.jep.2005.09.037
Qin S, Zhang YP, Chen X, Xia JY, Chen YD, Kong DM. Research on high throughput screening of drugs to inhibit macrophage migration (in Chinese). J. Guizhou Univ Tradit Chinese Medicine. 2020; 42, 87-90.
Qiu J, Zhu M, Wang Y, Chen B, Bai R, Chen F, Zhang L. Pharmacokinetic and excretion study of eight active constituents in rat by LC-MS/MS after oral administration of the Toddalia asiatica extract. Anal Biochem, 2022; 640:114407. https://doi.org/10.1016/j.ab.2021.114407
Rahmani M, Ling CY, Meon S, Ismail HBM, Sukari MA. The antifungal activity of Glycosmis calcicola and G. rupestris extracts. Pharm Biol, 2004; 42:430-3. https://doi.org/10.1080/13880200490886085
Raj MK, Balachandran C, Duraipandiyan V, Agastian P, Ignacimuthu S. Antimicrobial activity of Ulopterol isolated from Toddalia asiatica (L.) Lam.: a traditional medicinal plant. J Ethnopharmacol, 2012; 140(1):161-5. https://doi.org/10.1016/j.jep.2012.01.005
Rajkumar M, Chandra RH, Veeresham C. Production of nitidine from callus cultures of Toddalia asiatica. Int J Pharm Sci Nanotechnol, 2010; 3(2):1028-33. https://doi.org/10.37285/ijpsn.2010.3.2.18
Rajkumar M, Chandra RH, Asres K, Veeresham C. Toddalia asiatica (Linn.) Lam.-a comprehensive review. Pharmacogn Rev, 2008; 2(4):386-97.
Ren XD, Wang DW, Zhong L, Li SM, Guo SY. Effects of Long Jing 1 on isolated rat thoracic aortic rings. Chinese J Pathophysiol, 1993; 9:129-32.
Roshan, A. B., Venkatesh, H. N., Dubey, N. K., & Mohana, D. C. (2022). Chitosan-based nanoencapsulation of Toddalia asiatica (L.) Lam. essential oil to enhance antifungal and aflatoxin B1 inhibitory activities for safe storage of maize. Int J Biol Macromol, 2022; 204:476-84. https://doi.org/10.1016/j.ijbiomac.2022.02.026
Salahuddin M, Jalalpure SS. Antidiabetic activity of aqueous fruit extract of Cucumis trigonusRoxb. in streptozotocin-induced diabetic rats. J Ethnopharmacol, 2010; 127:565-7. https://doi.org/10.1016/j.jep.2009.10.018
Sblendorio V, Palmieri B. Accuracy of analyses for lipid profile parameters as measured with the CR3000 system. Eur Rev Med Pharmacol Sci, 2008; 12:191-6.
Singh VK, Chaurasia H, Mishra R, Srivastava R, Chaturvedi VK, Singh RK. Role of plant-based anti-hiv agents in hiv-associated neurocognitive disorders (Hand). In: Goyal MR, Birwal P, Mishra SK (eds.). Phytochemicals and medicinal plants in food design (pp. 25-44). Apple Academic Press, New York, 2022. https://doi.org/10.1201/9781003150336-3
Takomthong P, Waiwut P, Yenjai C, Sripanidkulchai B, Reubroycharoen P, Lai R, Kamau P, Boonyarat C. Structure-activity analysis and molecular docking studies of coumarins from Toddalia asiatica as multifunctional agents for Alzheimer's disease. Biomedicines, 2020; 8(5):107. https://doi.org/10.3390/biomedicines8050107
Thirugnanasampandan R, Jayakumar R, Prabhakaran M. Analysis of chemical composition and evaluation of antigenotoxic, cytotoxic and antioxidant activities of essential oil of Toddalia asiatica (L.) Lam. Asian Pac J Trop Biomed, 2012; 2(3):S1276-9. https://doi.org/10.1016/S2221-1691(12)60399-2
Tian PY, Yu YS, Deng ZG, Chen YK, Zhu X. Effects of Miao medicine Toddalia asiatica on acute gouty arthris in rats. Chinese J Gerontol, 2018; 3019-22.
Tong L, Chen T, Chen Z, Zhang P, Pi H, Ruan H, Wu J. Antiinflammatory activity of omphalocarpin isolated from Radix Toddalia asiatica. J Ethnopharmacol, 2014; 155:1553-60. https://doi.org/10.1016/j.jep.2014.07.055
Upendra RS, Ahmed MR. Healthcare prominence and immune boosting activity of ashwagandha against various clinical conditions and covid 19 disease outbreak. Int J Pharm Res, 2021; 489-97.
Upendra RS, Khandelwal P. Assessment of nutritive values, phytochemical constituents and biotherapeutic potentials of Epiphyllum oxypetalum. Int J Pharm Pharm Sci, 2012; 4(5):421-5.
Upendra RS, Khandelwal P, Manjunatha RAH. Turmeric powder (Curcuma longa Linn.) as an antifungal agent in plant tissue culture studies. Int J Eng Sci Technol, 2011; 3(11):7899-904.
Varsha DJ, Patil AV, Patil PC. Ethnomedicinal and pharmacognostical studies on leaves of Toddalia asiatica L. Der Pharmacia Sin, 2013; 4(4):76-80.
Vázquez R, Riveiro ME, Vermeulen M, Mondillo C, Coombes PH, Crouch NR, Ismail F, Mulholland DA, Baldi A, Shayo C, Davio C. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine, 2012; 19(8-9):737-46. https://doi.org/10.1016/j.phymed.2012.03.008
Wang F, Xu Y, Liu JK. New geranyloxycoumarins from Toddalia asiatica. J Asian Nat Prod Res, 2009; 11(8):752-6. https://doi.org/10.1080/10286020903048975
Wang QJ, Lu H, Lv WW, Liu F, Liu J. The experimental research on analgesia and anti-inflammation of aqueous extract from Toddalia asiatica Lam. Chinese J Exp Tradit Med Formulae, 2007; 13:35-7.
Yang K, Tong L, Chen C, Zhang P, Pi H, Ruan H, Wu J. Therapeutic effects of extracts from Radix Toddalia asiatica on collageninduced arthritis in Balb/c mice. J Ethnopharmacol, 2013; 146:355-62. https://doi.org/10.1016/j.jep.2013.01.004
Ye H, Li C, Ye W, Zeng F, Liu F, Liu Y, Li J. Medicinal Angiosperms of Rutaceae. In Common Chinese Materia Medica (pp. 519-622). Springer, Singapore, 2021. https://doi.org/10.1007/978-981-16-5888-4_10
Zeng Z, Tian R, Feng J, Yang NA, Yuan L. A systematic review on traditional medicine Toddalia asiatica (L.) Lam.: chemistry and medicinal potential. Saudi Pharm J, 2021; 29(8):781-98. https://doi.org/10.1016/j.jsps.2021.05.003
Zhang C, Zheng X, Ni H, Li P, & Li, H. J. Discovery of quality control markers from traditional Chinese medicines by fingerprint-efficacy modeling: Current status and future perspectives. J Pharm Biomed Anal, 2018; 159:296-304. https://doi.org/10.1016/j.jpba.2018.07.006
Zhu M, Wei P, Peng Q, Qin S, Zhou Y, Zhang R, Zhang L. Simultaneous qualitative and quantitative evaluation of Toddalia asiatica root by using HPLC-DAD and UPLC-QTOF-MS/MS. Phytochem Anal, 2019; 30(2):164-81.https://doi.org/10.1002/pca.2802
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