A review of the cosmetic use and potentially therapeutic importance of hyaluronic acid

Lidia K. Al-Halaseh Nariman A. Al-Jawabri Shahed K. Tarawneh Wasan K. Al-Qdah Maha N. Abu-Hajleh Ali M. Al-Samydai Mai A. Ahmed   

Open Access   

Published:  May 19, 2022


Hyaluronic acid (HA) is an endogenous substance detected and isolated from various tissues and biological fluids. Owing to its physicochemical properties, HA contributes to many biological processes at intra- and extracellular levels, such as skin hydration, joints lubrication, and wound healing, besides its anti-inflammatory and antioxidant effects. The current review highlights the employment of exogenous HA in many aesthetic and dermatological aspects. Also, it aims to clarify the skin rejuvenating activity by compensating for the biological loss of HA with advanced age. Other positive impacts of HA on hair, nail, and overall health status were also revised. Cosmetics and cosmeceuticals that contain HA, among other active ingredients, are commercially available in different dosage forms such as gels, creams, intradermal injections, and fillers. Aesthetic enhancement is achieved via soft tissue augmentation, skin hydration level increasing, grooves refilling, and collagen and elastin biosynthesis stimulation. HA contributes to various therapeutic approaches such as gingivitis, stomatitis, ulceration, and osteoarthritis. Additionally, it has beneficial uses in dentistry due to its antioxidant and anti-inflammatory properties. The recent implication of HA following the claims that it has a rejuvenating power for the skin and many therapeutic benefits has to be thoroughly investigated and delivered by a trained expert to avoid undesirable effects.

Keyword:     Hyaluronic acid dermatology cosmeceuticals hyaluronan skincare filler.


Al-Halaseh LK, Al-Jawabri NA, Tarawneh SK, Al-Qdah WK, Abu-Hajleh MN, Al-Samydai AM, Ahmed MA. A review of the cosmetic use and potentially therapeutic importance of hyaluronic acid. J Appl Pharm Sci, 2022. Online First.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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