Two simple, accurate and sensitive spectrophotometric methods were developed for the determination of ticlabendazole in bulk and pharmaceutical formulation. These methods were based on the formation of ion-pair association complex (1:1) with bromocresol purple (BCP) and bromophenol blue (BPB). The coloured products were extracted into chloroform and measured spectrophotometrically at 420 nm. Linearity ranges were 20 – 100 μg/ml for BCP and 10 – 100μg/ml for BPB, the mean percentage recoveries were 99.61±1.152% and 99.60±0.986% for BCP and BPB respectively. Statistical comparison between the results obtained by these methods and the manufacturer’s method was done, and no significance difference was obtained.
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