Research Article | Volume : 1 Issue : 10, December 2011

Isolation of wound healing compounds from Heliotropium indicum

Dodehe Yeo Barthélémy Attioua Christine Lehalle Metowogo Kossi Jean David N’guessan Allico Joseph Djaman Annelise Lobstein Nelly Frossard   

Open Access   

Abstract

Heliotropium indicum (Boraginaceae) is used in the traditional Ivory Coast pharmacopeia to treat asthma. In the present study, wound healing effect of n- butanol fractions was evaluated in H292- cells. Fractions which possessed better wound healing activity were fractionated on Sephadex LH20 column chromatography. Two compounds have been isolated which were responsible for this wound healing effect. Their structures were established as Pestalamide B (1) and Glycinamide,N-(1-oxooctadecyl)glycyl-L-alanylglycyl-L-histidyl (2) on the basis of spectral analysis. Both compound 1 and 2 presented wound healing effect compared with the control(P


Keyword:     Heliotropium indicumBoraginaceaeIsolationWound healingH292-Cells


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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