Research Article | Volume : 1 Issue : 10, December 2011

Isolation of wound healing compounds from Heliotropium indicum

Dodehe Yeo,  Barthélémy Attioua,  Christine Lehalle,  Metowogo Kossi,  Jean David N’guessan,  Allico Joseph Djaman,  Annelise Lobstein,  Nelly Frossard   
Dodehe Yeo1, Barthélémy Attioua3, Christine Lehalle2, Metowogo Kossi4, Jean David N’guessan1, Allico Joseph Djaman1, Annelise Lobstein5, Nelly Frossard2

1Laboratoire de Pharmacodynamie Biochimique, Université de CocodyAbidjan, Ivory Coast, 22 BP 582 Abidjan 22.

2Laboratoire d’Innovation Thérapeutique, Faculté de Pharmacie, Université de Strasbourg, France.

3Laboratoire de Chimie Organique, Université de Cocody-Abidjan, Ivory Coast 22 BP 582 Abidjan 22.

4Laboratoire de Physiologie & Pharmacologie, Université de Lomé, BP 1515 Togo.

5Unité de Pharmacognosie, UMR UDS/CNRS 7200, Faculté de Pharmacie, Université Louis De Strasbourg, France.

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Abstract

Heliotropium indicum (Boraginaceae) is used in the traditional Ivory Coast pharmacopeia to treat asthma. In the present study, wound healing effect of n- butanol fractions was evaluated in H292- cells. Fractions which possessed better wound healing activity were fractionated on Sephadex LH20 column chromatography. Two compounds have been isolated which were responsible for this wound healing effect. Their structures were established as Pestalamide B (1) and Glycinamide,N-(1-oxooctadecyl)glycyl-L-alanylglycyl-L-histidyl (2) on the basis of spectral analysis. Both compound 1 and 2 presented wound healing effect compared with the control(P


Keyword:     Heliotropium indicumBoraginaceaeIsolationWound he

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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