A natural approach to control induced fumonisin B1-histopathological nephrotoxic and hepatotoxic changes in rats

Ashraf A Khalil; Ashgan Abou Gabal; Amira A Abdellatef; Noha M Zahran; Sahar F Deraz

doi:10.7324/JAPS.2019.S103

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Abstract

Among liver and kidney diseases, mycotoxin contamination of feed has become a major concern in animal feed science. A case control study was conducted to evaluate the recovery efficiency of lactic acid bacteria on serum lipid profile parameters and histopathological changes of nephrotoxic and hepatotoxic mycotoxin fumonisin B1 (FB1)- induced toxicity in kidney and liver of rats. Eighteen rats were randomly assigned to 12 experimental groups fed various doses of FB1 and/or co-administrated Lactobacillus delbrueckii subsp. lactis DSM 20076 (LL-DSM) and Pediococcus acidilactici NNRL B-5627 (PA-NNRL) for a period of 28 days. After 2 weeks, no significant signs of toxicity in rats fed FB1 alone or co-administrated with LAB were observed. Treatments of LL-DSM and/or PA-NNRL had no effect on organs weight, lipid profile, and histopathological examination of kidney and liver tissues along the experimental period. After 4 weeks, low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol, triglycerides and total cholesterol were significantly increased, however the HDL-C, kidney and liver weights were significantly decreased in animals fed FB1 at doses tested. In the same line, the histopathological examination of livers and kidneys showed a series of morphological alterations in animals fed FB1, especially at the high dose (T200). Administration of LAB resulted in a significant improvement in all treatments tested as well as the histopathological patterns of liver and kidney tissues. Thus, using either LL-DSM or PA-NNRL strains could potentially expand another choice for safeguard application against immunotoxicities induced by fumonisins in many farm animal species that face inattentive exposition to this class of mycotoxins in their feedstuff.

Keyword: Histopathology lipid profile hepatotoxicity nephrotoxicity fumonisins LAB detoxification.

Citation:

Khalil AA, Gabal AA, Abdellatef AA, Zahran NM, Deraz SF. A natural approach to control induced fumonisin B1- histopathological nephrotoxic and hepatotoxic changes in rats. J Appl Pharm Sci, 2019; 9(S1):017–029.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Khalil A A [PubMed] [Google Scholar ]

Gabal A A [PubMed] [Google Scholar ]

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Abdel-Wahhab M, Amer H, Hassan N, Hassan A, Naguib K. Effects of garlic and cabbage extracts on fuminisin-induced toxicity in rats. J Egypt Soc Toxicol, 2002; 26:1–12.

Abdel-Wahhab MA, Hassan AM, Amer HA, Naguib KM. Prevention of fumonisin-induced maternal and developmental toxicity in rats by certain plant extracts. J App Toxicol, 2004; 24:469–74. https://doi.org/10.1002/jat.1000

Aliabadi MA, Alikhani FE, Mohammadi M, Darsanaki RK. Biological control of aflatoxins. Eur J Exp Biol, 2013; 3:162–6.

Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem, 1974; 20:470–5.

Ben Salah-Abbès J, Jebali R, Sharafi H, Noghabi KA, Oueslati R, Abbès S. Immuno-physiological alterations from AFB1 in rats counteracted by treatments with Lactobacillus paracasei BEJ01 and montmorillonite clay mixture. J Immunotoxicol, 2016; 13:628–37. https://doi.org/10.3109/1547691X.2016.1145157

Bennett J. Mycotoxins, mycotoxicoses, mycotoxicology and mycopathologia. Mycopathologia, 1987; 100:3–5. https://doi.org/10.1007/BF00769561

Bondy G, Barker M, Mueller R, Fernie S, Miller JD, Armstrong C, Hierlihy SL, Rowsell P, Suzuki C. Fumonisins B1 toxicity in male Sprague-Dawley rats. In: Jackson LS, De Vries JW, Bullerman LB (eds.). Fumonisins in food (advances in experimental medicine and biology). Plenum Press, New York, pp 251–64, . https://doi.org/10.1007/978-1-4899-1379-1_22

Bondy GS, Suzuki CAM, Mueller RW, Fernie SM, Armstrong CL, Hierlihy SL, Savard ME, Barker MG. Gavage administration of the fungal toxin fumonisin B1 to female Sprague-Dawley rats. J Toxicol Environ Health, 1998; 53:135–51. https://doi.org/10.1080/009841098159411

Bucolo G, David H. Quantitative determination of serum TGs by the use of enzymes. Clin Chem, 1973; 19:476–82.

Bulder AS, Arcella D, Bolger M, Carrington C, Kpodo K, Resnik S, Riley RT, Wolterink G, Wu F. Fumonisins (addendum). In: World Health Organization (ed.). Safety evaluation of certain food additives and contaminants, WHO Food Additives Series 65, WHO, Geneva, pp 325–794, 2012.

Burstein M, Samaille J. On a rapid determination of the cholesterol bound to the serum alpha-and beta-lipoproteins. Clin Chim Acta, 1960; 5:609 (in French). https://doi.org/10.1016/0009-8981(60)90075-9

Connerty HV, Briggs AR, Eaton Jr EH. Determination of serum, phospholipids, lipid phosphorous. In: Varley H (ed.). Practical clinical biochemistry, CBS Publishers, India, pp 319–20, 1961.

Dang HA, Zsolnai A, Kovacs M, Bors I, Bonal A, Bota B, Szabo-Fodor J. In vitro interaction between fumonisin B1 and the intestinal microflora of pigs. Pol J Microbiol, 2017; 66, 245–50. https://doi.org/10.5604/01.3001.0010.7858

Domijan AM, Peraica M, Vrdoljak AL, RadiÄ‡ B, Å½lender V, Fuchs R. The involvement of oxidative stress in ochratoxin A and fumonisin B1 toxicity in rats. Mol Nutr Food Res, 2007; 51:1147–51. https://doi.org/10.1002/mnfr.200700079

Eknoyan G, Lameire N, Eckardt K, Kasiske B, Wheeler D, Levin A, Stevens P, Bilous R, Lamb E, Coresh J. Kidney disease: improving global outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int, 2013; 3:5–14.

El-Nekeety AA, El-Kholy W, Abbas NF, Ebaid A, Amra HA, AbdelWahhab MA. Efficacy of royal jelly against the oxidative stress of fumonisin in rats. Toxicon, 2007; 50:256–69. https://doi.org/10.1016/j.toxicon.2007.03.017

El-Nezami H, Kankaanpää P, Salminen S, Ahokas J. Ability of dairy strains of lactic acid bacteria to bind a common food carcinogen, aflatoxin B1. Food Chem Toxicol, 1998; 36:321–6. https://doi.org/10.1016/S0278-6915(97)00160-9

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