Research Article | Volume: 8, Issue: 9, September, 2018

Stability Study of Ipomoea reptans Extract Self-Nanoemulsifying Drug Delivery System (SNEDDS) as Anti-Diabetic Therapy

Pinus Jumaryatno Lutfi Chabib Farida Hayati Rizki Awaluddin   

Open Access   

Published:  Sep 30, 2018

DOI: 10.7324/JAPS.2018.8903

Diabetes mellitus (DM) is one of the metabolic syndromes that is characterized by the excessive accumulation of blood glucose, also called as hyperglycemia, and carbohydrate, fat, and protein metabolism disorder. The antioxidant compounds on Ipomoea reptans possess the pharmacological activity of DM with low absorption in the systemic circulation. Stability is one of the factors that affect the safety, quality, and efficacy of the SNEDDS (Self- Nanoemulsifying Drug Delivery) dosage form. This study aimed to evaluate the stability of Ipomoea reptans leaf extract (IPE) SNEDDS. The IPE SNEDDS was made using capryol 90 as the oil phase, tween 20 as surfactants, and polyethylene glycol (PEG) 400 as the cosurfactant. The stability study was conducted with several physical stability tests, which were centrifugation test, heating-cooling cycle test, and freeze-thaw cycle test. The result indicated that the particle size of the IPE SNEDDS was ≤100 nm and indicated good physical stability. It can be concluded that the IPE SNEDDS possesses good stability profile.

Keyword:     Ipomoea reptans SNEDDSStability Capryol 90Diabetes Mellitus.


Jumaryatno P, Chabib L, Hayati F, Awaluddin R. Stability Study of Ipomoea reptans Extract Self-Nanoemulsifying Drug Delivery System (SNEDDS) as Anti-Diabetic Therapy. J App Pharm Sci, 2018; 8(09): 011-014.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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